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Salivary Proteomics for Detecting Novel Biomarkers of Periodontitis: A Systematic Review.
J Periodontal Res
December 2024
Department of Surgical Sciences, C.I.R. Dental School, University of Turin, Turin, Italy.
Aim: Salivary content is regarded as a powerful diagnostic window for oral and systemic diseases and the proteomic profile could be useful to distinguish between different periodontal conditions. The aim of the present systematic review was to assess distinctive salivary proteins identified through untargeted proteomics in periodontitis patients compared to periodontally healthy and gingivitis subjects, as well as to provide a qualitative methodological assessment of the current literature.
Methods: Relevant studies identified from Medline via PubMed, Scopus, Embase, and Cochrane Library databases were retrieved to answer the following PECO question: "In systemically healthy individuals, are there any differences in salivary protein expression profiles assessed in proteomics studies between patients with periodontitis and periodontally healthy or gingivitis subjects?" Moreover, diagnostic utility of the identified markers was sought via a targeted literature search and further quantitative assessment.
[Component-resolved diagnostics of fruit and vegetable allergy: precise identification and individualized treatment strategies].
Zhonghua Yu Fang Yi Xue Za Zhi
October 2024
Department of Clinical Laboratory, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou 510120, China.
Article Synopsis
- - Vegetable and fruit allergies are often linked to pollen sensitization, with common allergens being proteins like PR-10, profilins, and nsLTPs that cause cross-reactivity.
- - Component-resolved diagnostics (CRD) enhance allergy testing by identifying specific allergenic proteins, improving treatment decisions and reducing unnecessary food restrictions.
- - The article, based on the "Molecular Allergology User's Guide 2.0," explores mechanisms, allergens, and management strategies for these allergies, aiming to enhance healthcare professionals' understanding and support personalized treatment approaches.
Spinal Muscular Atrophy (SMA) is a neuromuscular disease caused by low levels of the Survival of Motoneuron (SMN) protein. SMN interacts with and regulates the actin-binding protein profilin2a, thereby influencing actin dynamics. Dysfunctional actin dynamics caused by SMN loss disrupts neurite outgrowth, axonal pathfinding, and formation of functional synapses in neurons.
View Article and Find Full Text PDFConcomitant presence of a novel ARPP21 variant and CNVs in Chinese familial amyotrophic lateral sclerosis-frontotemporal dementia patients.
Neurol Sci
January 2025
Institute of Medical Innovation and Research, Peking University Third Hospital, Beijing, 100191, China.
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder marked by the degeneration of motor neurons and progressive muscle weakness. Heredity plays an important part in the pathogenesis of ALS. Recently, with the emergence of the oligogenic pathogenic mechanism in ALS and the ongoing discovery of new mutated genes and genomic variants, there is an emerging need for larger-scale and more comprehensive genetic screenings in higher resolution.
View Article and Find Full Text PDFPFN1 Knockdown Aggravates Mitophagy to Retard Lung Adenocarcinoma Initiation and M2 Macrophage Polarization.
Mol Biotechnol
August 2024
Department of Oncology, Xuzhou Central Hospital, 199 Jiefang South Road, XuZhou, 221000, Jiangsu, China.
Tumor-associated macrophages (TAM) are considered as crucial influencing factors of lung adenocarcinoma (LUAD) carcinogenesis and metastasis. Profilin 1 (PFN1) has been proposed as a potent driver of migration and drug resistance in LUAD. The focus of this work was to figure out the functional mechanism of PFN1 in macrophage polarization in LUAD.
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