Background: Patients with metastatic poorly differentiated endocrine carcinoma (PDEC) usually have a short survival. The chemotherapy combination of cisplatin and etoposide is frequently used as first-line palliative chemotherapy. There are, however, no published studies concerning second-line treatment of the disease. Temozolomide has shown clinical effect in well-differentiated endocrine carcinomas. This study was performed to evaluate the effect of temozolomide in PDEC patients who had progressed on first-line treatment.
Methods: Twenty-five patients with PDEC (mainly gastrointestinal) were treated with temozolomide alone or in combination with capecitabine. A subset of patient also received bevacizumab. MGMT methylation was analyzed in tissue specimens. Data were collected retrospectively.
Results: One patient had a complete response, and 7 patients had partial response (33% response rate). Median duration of response was 19 months. Another 9 (38%) patients had a stable disease, after progression at inclusion, with a median duration of 18 months. Median progression-free survival for all patients was 6 months, and median overall survival was 22 months. Only 1 patient had a MGMT methylation.
Conclusions: Treatment with temozolomide alone or in combination with capecitabine and bevacizumab resulted in objective response or stabilization in 71% of PDEC patients who failed on first-line chemotherapy. These results indicated that temozolomide may be used as second-line treatment in PDEC.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/cncr.26124 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
NAD Promotes Superovulation of Huaxi Cattle Through Regulation of Cumulus Cell Proliferation and Oocyte Maturation.
Int J Mol Sci
March 2025
State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Science, Inner Mongolia University, Hohhot 010070, China.
Superovulation and embryo transfer are key technologies to improve the reproductive ability of female animals and enhance the efficiency of livestock production. However, poor-quality oocytes or abnormal fluctuations of hormone levels caused by superovulation affect the embryonic development environment, which may lead to a significant decline in the number and quality of transferable embryos, thus reducing the efficiency of superovulation. In this study, nicotinamide adenine dinucleotide (NAD) was injected into Huaxi cows during the superovulation period to observe the proliferation and apoptosis of transplanted embryos.
View Article and Find Full Text PDFCharacterizing the Ovarian Cytogenetic Dynamics of Sichuan Bream () During Vitellogenesis at a Single-Cell Resolution.
Int J Mol Sci
March 2025
Integrative Science Center of Germplasm Creation in Western China (Chongqing) Science City, Southwest University, Chongqing 401329, China.
Vitellogenesis in fish represents a critical phase of oogenesis, significantly influencing the nutritional provisioning for oocyte maturation and subsequent offspring development. However, research on the physiological mechanisms governing vitellogenesis at the single-cell level remains limited. In this study, we performed single-nucleus RNA sequencing (snRNA-seq) on the ovaries of Sichuan bream ().
View Article and Find Full Text PDFCircGRB14 Inhibits Proliferation and Promotes Apoptosis of Granulosa Cells in Chicken Follicle Selection Through Sponging miR-12264-3p and miR-6660-3p.
Int J Mol Sci
February 2025
State Key Laboratory of Animal Biotech Breeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
The development and selection of ovarian follicles are essential for continuous egg production in chickens. Non-coding RNAs, particularly circular RNAs (circRNAs), play a critical regulatory role in follicle selection, a process heavily involving granulosa cells (GCs). In this study, we analyzed circRNA expression profiles in small yellow follicles (SYFs) and large yellow follicles (LYFs) of Taihang chickens using RNA sequencing.
View Article and Find Full Text PDFDynamic Transcriptional Regulation of the Hypothalamic-Pituitary-Testis Axis in the Seasonally Breeding Teleost .
Int J Mol Sci
February 2025
CAS and Shandong Province Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266000, China.
Spermatogenesis, the process of male germ cell development, is tightly regulated by the hypothalamic-pituitary-testis (HPT) axis in seasonally breeding teleosts. Despite its importance, our understanding of how the brain and male germ cells coordinate key transitions-such as testis initiation and maturation-remains limited, particularly in species with distinct seasonal reproductive cycles. Black rockfish (), a marine viviparous teleost, exhibits a prolonged testis quiescent phase lasting three-quarters of the year, with testis initiation occurring in September and maturation concluding in November and December.
View Article and Find Full Text PDFTGF-β1 Mediates Novel-m0297-5p Targeting to Participate in the Proliferation of Ovarian Granulosa Cells in Small-Tailed Han Sheep.
Int J Mol Sci
February 2025
Key Laboratory of Herbivorous Animal Biotechnology, Faculty of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China.
MiRNAs regulate follicle development and atresia, steroid production, granulosa cell (GC) proliferation, and apoptosis. However, the target genes and the functioning of novel miRNAs remain unexplored. We reveal the targeting relationship between novel-m0297-5p and and the specific regulatory mechanism of GC proliferation in small-tailed Han sheep using whole transcriptomic sequencing.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!