AI Article Synopsis
- The study investigates the prognostic factors affecting the survival of intrahepatic cholangiocarcinoma (ICC) patients, particularly focusing on the role of chronic hepatitis B virus (HBV) infection.
- A total of 155 ICC patients were analyzed, with 60.6% surviving one year and 32.1% surviving three years; key factors influencing survival included HBV infection and lymphatic metastasis.
- The findings suggest that ICC patients with HBV present different clinical characteristics compared to those without HBV, highlighting the importance of differentiating these groups for better prognosis and treatment planning.
Article Abstract
Aim: To study the prognostic factors for intrahepatic cholangiocarcinoma (ICC) and evaluate the impact of chronic hepatitis B virus (HBV) infection on survival rate of ICC patients.
Methods: A total of 155 ICC patients who underwent macroscopic curative resections (R0 and R1) were enrolled in this retrospective study and divided into group A with HBV infection and group B without HBV infection according to their chronic HBV infection, represented by positive hepatitis B surface antigen (HBsAg) in serum or in liver tissue. Clinicopathological characteristics and survival rate of the patients were evaluated.
Results: All patients underwent anatomical resection. Their 1- and 3-year survival rates were 60.6% and 32.1%, respectively. Multivariate analyses revealed that HBV infection, hepatolithiasis, microscopic satellite lesion, and lymphatic metastasis were the independent prognostic factors for the survival rate of ICC patients. The median disease-free survival time of the patients was 5.0 mo. The number of tumors, microscopic satellite lesion, and vascular invasion were the independent prognostic factors for the disease-free survival rate of the patients. The prognostic factors affecting the survival rate of ICC patients with HBV infection and those without HBV infection were not completely consistent. Alkaline phosphatase > 119 U/L, microscopic satellite lesion, vascular invasion, and lymphatic metastasis were the independent factors for the patients with HBV infection, while r-glutamyltransferase > 64 U/L, microscopic satellite lesion, and poor tumor differentiation were the independent factors for the patients without HBV infection.
Conclusion: HBV infection is a valuable clinical factor for predicting tumor invasiveness and clinical outcome of ICC patients. ICC patients with HBV infection should be distinguished from those without HBV infection because they have different clinicopathological characteristics, prognostic factors and outcomes after surgical resection.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068264 | PMC |
| http://dx.doi.org/10.3748/wjg.v17.i10.1292 | DOI Listing |
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