Introduction: Optimising haemoglobin (Hb) levels less than 13 g/dl in the preoperative period can reduce the transfusion rate. With this aim, we developed a multidisciplinary protocol in our hospital for the treatment of patients proposed for colorectal cancer surgery.
Patients And Method: A study was conducted on 437 patients who had surgery performed for colorectal cancer in the period 2005-2009. The data recorded were: demographic data, Hb and iron metabolism (Fe) at the time of diagnosis, Hb on the day of the surgery and on discharge, tumour location, preoperative adjuvant treatment (chemotherapy and/or radiotherapy), tumour stage (TNM), iron treatment, transfusion rate, and complications at 30 days. Patients were classified into Group A; Hb < 13 g/dl and/or abnormal Fe metabolism, and Group B; Hb > 13 g/dl and/or normal Fe metabolism.
Results: Of the total, 53.3% were in Group B and were treated with Fe; 73.6% intravenous (IV), and the rest oral. The mean dose of IV Fe was 867 mg. The mean intraindividual difference between the Hb on the day of surgery and at the initial value, increased by 0.6g/dl in Group A, while it decreased by 0.8 g/dl in Group B. The mean intraindividual difference between the Hb at discharge and the diagnosis decreased by 0.4 g/dl in Group A compared to 2.5 g/dl in Group B. The overall transfusion rate was 8.6%. No statistically significant differences were observed in complications.
Conclusions: A multidisciplinary and early treatment of colorectal cancer enables patients with a low haemoglobin (Group A) to be optimised, as well as achieving a lower transfusion rate.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ciresp.2011.01.013 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Risk Prediction Model of Peristomal Skin Complications Among Patients with Colorectal Cancer and an Ostomy: A Cross-sectional Study in Shanghai, China.
Adv Skin Wound Care
January 2025
Li-li Ma, MSc, RN, is PhD Candidate, Medical College, Tongji University, Shanghai, China Department of Nursing, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China. Ya-juan Zhang, MSc, RN, is Head Nurse, Department of Nursing, Shanghai Sixth People's Hospital, School of Medicine, Jiao Tong University, Shanghai. Hui-ren Zhuang, MSc, RN, is Department Head Nursing, Department of Nursing, Shanghai East Hospital, School of Medicine, Tongji University. Hui Jiang, PhD, RN, is Nursing Director, Department of Nursing, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University.
Objective: To analyze the risk factors for peristomal skin complications (PSCs) in patients with colorectal cancer and an ostomy, construct a prediction model, and verify its effectiveness.
Methods: In this cross-sectional study, researchers recruited 265 patients with an ostomy at the stoma clinic of a tertiary hospital, from May 2022 to August 2023. Patients were divided into two groups: complications group (n = 81) and no complications group (n = 184).
Laparoscopic treatment of perineal hernia after previous abdominal perineal rectal resection due to cancer. Case report.
Wiad Lek
January 2025
DEPARTMENT OF GENERAL, ONCOLOGICAL AND DIGESTIVE TRACT SURGERY, MEDICAL CENTRE OF POSTGRADUATE EDUCATION, ORŁOWSKI HOSPITAL, MEDICAL CENTRE OF POSTGRADUATE EDUCATION, WARSAW, POLAND.
The aim of this study is to present a case of laparoscopic treatment of perineal hernia in a patient after abdominoperineal resection od the rectum. We present the case of a 63-year-old woman who was operated on laparoscopically with a mesh sewn in at the level of the sacrum, iliac vessels and pubic symphysis. And covered with a peritoneal flap above the urinary bladder.
View Article and Find Full Text PDFPhytochemical analysis of ethanolic leaf extract of Cordia myxa and its anti-Inflammatory and cytotoxic activities.
Wiad Lek
January 2025
DEPARTMENT OF PHARMACOLOGY AND TOXICOLOGY, FACULTY OF PHARMACY, UNIVERSITY OF KUFA, KUFA, IRAQ.
Objective: Aim: Testing Cordia myxa extract on colon cancer cell line and caspase-3 gene and COX-2 protein expression.
Patients And Methods: Materials and Methods: This study used Cordia myxa ethanolic extract at various dosages on SW480 cells. Cell proliferation was measured using MTT, also examined effect of Cordia myxa extract on caspase-3 gene expression using quantitative real-time polymerase chain reaction.
Lupus and inflammatory bowel disease share a common set of microbiome features distinct from other autoimmune disorders.
Ann Rheum Dis
January 2025
Meinig School of Biomedical Engineering, Cornell University, Ithaca, New York, USA. Electronic address:
Objectives: This study aims to elucidate the microbial signatures associated with autoimmune diseases, particularly systemic lupus erythematosus (SLE) and inflammatory bowel disease (IBD), compared with colorectal cancer (CRC), to identify unique biomarkers and shared microbial mechanisms that could inform specific treatment protocols.
Methods: We analysed metagenomic datasets from patient cohorts with six autoimmune conditions-SLE, IBD, multiple sclerosis, myasthenia gravis, Graves' disease and ankylosing spondylitis-contrasting these with CRC metagenomes to delineate disease-specific microbial profiles. The study focused on identifying predictive biomarkers from species profiles and functional genes, integrating protein-protein interaction analyses to explore effector-like proteins and their targets in key signalling pathways.
Lobaric acid suppresses the stemness potential of colorectal cancer cells through mTOR/AKT.
Biofactors
January 2025
College of Pharmacy, Sunchon National University, Sunchon, Republic of Korea.
Stereocaulon alpinum has been found to have potential pharmaceutical properties due to the presence of secondary metabolites such as usnic acid, atranorin, and lobaric acid (LA) which have anticancer activity. On the other hand, the effect of LA on the stemness potential of colorectal cancer (CRC) cells remains unexplored, and has not yet been thoroughly investigated. In this study, we examined the inhibitory activity of LA from Stereocaulon alpinum against the stemness potential of CRC cells and investigated the possible underlying mechanisms.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!