Biological data is often tabular but finding statistically valid connections between entities in a sequence of tables can be problematic--for example, connecting particular entities in a drug property table to gene properties in a second table, using a third table associating genes with drugs. Here we present an approach (CRIT) to find connections such as these and show how it can be applied in a variety of genomic contexts including chemogenomics data.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3129682PMC
http://dx.doi.org/10.1186/gb-2011-12-3-r32DOI Listing

Publication Analysis

Top Keywords

crit framework
4
framework identifying
4
identifying cross
4
cross patterns
4
patterns systems
4
systems biology
4
biology application
4
application chemogenomics
4
chemogenomics biological
4
biological data
4

Similar Publications

Heavy metal pollution is a major environmental and health problem due to the toxicity and persistence of metals such as lead, mercury, cadmium, and arsenic in water, soil, and air. Advances in sensor technology have significantly improved the detection and quantification of heavy metals, providing real-time monitoring and mitigation tools. This review explores recent developments in heavy metal detection, focusing on innovative uses of immobilized chromogenic reagents, nanomaterials, perovskites, and nanozymes.

View Article and Find Full Text PDF

Impact of a Quality Cardiopulmonary Resuscitation Coach on Pediatric Intensive Care Unit Resuscitation Teams.

Am J Crit Care

January 2025

Christine A. Schindler is a critical care pediatric nurse practitioner, critical care advanced practice provider program director, Children's Wisconsin/Medical College of Wisconsin, and a clinical professor, Marquette University, Milwaukee, Wisconsin.

Background: The quality cardiopulmonary resuscitation (CPR) coach role was developed for hospital-based resuscitation teams. This supplementary team member (CPR coach) provides real-time, verbal feedback on chest compression quality to compressors during a cardiac arrest.

Objectives: To evaluate the impact of a quality CPR coach training intervention on resuscitation teams, including presence of coaches on teams and physiologic metrics of quality CPR delivery in real compression events.

View Article and Find Full Text PDF

Patient and family member experience of hospital readmission following critical illness.

Intensive Crit Care Nurs

December 2024

Intensive Care Unit, Glasgow Royal Infirmary, Glasgow, UK; Intensive Care Unit, Belfast City Hospital, Belfast, UK.

Background: Hospital readmission following critical illness is common. There is limited data which examines the patient and family perspective of hospital readmission. Understanding the impact of readmissions from a patient perspective can potentially help design meaningful clinical pathways to support improvements in care.

View Article and Find Full Text PDF

A systematic review of the comparative effects of sound and music interventions for intensive care unit patients' outcomes.

Aust Crit Care

December 2024

Department of Music, Canadian Centre for Ethnomusicology (CCE), Department of Performing Arts, Faculty of Communication and Media Studies, University for Development Studies, Ghana; Department of Music, Faculty of Arts, University of Alberta, 3-98 Fine Arts Building, Edmonton, AB, T6G 2C9, Canada. Electronic address:

Background: Despite syntheses of evidence showing efficacy of music intervention for improving psychological and physiological outcomes in critically ill patients, interventions that include nonmusic sounds have not been addressed in reviews of evidence. It is unclear if nonmusic sounds in the intensive care unit (ICU) can confer benefits similar to those of music.

Objective: The aim of this study was to summarise and contrast available evidence on the effect of music and nonmusic sound interventions for the physiological and psychological outcomes of ICU patients based on the results of randomised controlled trials.

View Article and Find Full Text PDF

Physical function measures in ICU survivors, where to now? A scoping review.

South Afr J Crit Care

July 2024

Division of Physiotherapy, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.

Background: Growing evidence is describing the long-term morbidity experienced by critical illness survivors, a major contributing factor being impaired physical function. Consensus is yet to be reached on which physical function measures should be included in this population. This review aimed to describe physical functioning measurement instruments used in longitudinal studies of critical illness survivors, based on the International Classification of Function (ICF).

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!