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Sequential injection analysis (SIA) technique with a miniaturized fibre optic spectrophotometry was exploited to optimize and validate a new method for the assay of verapamil in pharmaceutical formulations. The reduction of acidified permanganate by verapamil was spectrophotometrically detected at 546 nm. The 2(3) full-factorial design was adopted for screening the effect of conditions controlling the proposed method, and accordingly for the purpose of optimization. The remarkable advantages of the method are high rapidity (sample frequency was 10.6 samples/h), saving in reagents and sample (total consumed volume was 190 µl) and better safety for the environment (total waste production volume was 2140 µl). Additionally, the method was selective in the presence of excipients usually found in tablet and injection formulations. The average of recovery in synthetic samples as well as dosage forms was 98.8-103.0%. The obtained results were realized by the British Pharmacopoeia method and comparable results were obtained.
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