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Directed evolution of antimicrobial peptides using multi-objective zeroth-order optimization.
Brief Bioinform
November 2024
School of Computer Science and Technology, Harbin Institute of Technology, HIT Campus, Shenzhen University Town, Nanshan District, Shenzhen 518055, Guangdong, China.
Antimicrobial peptides (AMPs) emerge as a type of promising therapeutic compounds that exhibit broad spectrum antimicrobial activity with high specificity and good tolerability. Natural AMPs usually need further rational design for improving antimicrobial activity and decreasing toxicity to human cells. Although several algorithms have been developed to optimize AMPs with desired properties, they explored the variations of AMPs in a discrete amino acid sequence space, usually suffering from low efficiency, lack diversity, and local optimum.
View Article and Find Full Text PDFNeuronal dynamics of cerebellum and medial prefrontal cortex in adaptive motor timing.
Nat Commun
January 2025
Department of Neuroscience, Erasmus MC, Westzeedijk 353, 3015 AA, Rotterdam, the Netherlands.
Precise temporal control of sensorimotor coordination and adaptation is a fundamental basis of animal behavior. How different brain regions are involved in regulating the flexible temporal adaptation remains elusive. Here, we investigated the neuronal dynamics of the cerebellar interposed nucleus (IpN) and the medial prefrontal cortex (mPFC) neurons during temporal adaptation between delay eyeblink conditioning (DEC) and trace eyeblink conditioning (TEC).
View Article and Find Full Text PDFFrom Escalate to Elevate: A New Paradigm for Comprehensive Cardiogenic Shock Management.
Can J Cardiol
January 2025
Ted Rogers Centre for Heart Research, University Health Network, Toronto, ON, Canada; Division of Cardiology, Peter Munk Cardiac Centre, University Health Network, Toronto, ON, Canada. Electronic address:
Patients with cardiogenic shock (CS) present with critical hemodynamic compromise with low cardiac output (CO) resulting in end-organ dysfunction. Prognosis is closely related to the severity of shock and treatment of patients with CS is resource intensive. In this review, we consider the current treatment paradigms alongside the evidence that underpins them.
View Article and Find Full Text PDFVermont's Universal School Meals Program: Challenging the Neoliberal Education Paradigm.
J Nutr Educ Behav
January 2025
Department of Community Development and Applied Economics, The University of Vermont, Burlington, VT. Electronic address:
This article examines the recent implementation of Universal School Meals (USM) programs in several US states in the context of the increasing influence of neoliberalism in the public schooling system. By subverting a neoliberal paradigm, USM programs disrupt prevailing narratives of poverty and work to reclaim education's central place in the public sphere. A systems-thinking analysis of this issue reveals USM programs to be a powerful leverage point for change.
View Article and Find Full Text PDFLong-term neurobehavioral and neuroimaging outcomes in athletes with prior concussion(s) and head impact exposure.
Clin Neuropsychol
January 2025
Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, USA.
The long-term health of former athletes with a history of multiple concussions and/or repetitive head impact (RHI) exposure has been of growing interest among the public. The true proportion of dementia cases attributable to neurotrauma and the neurobehavioral profile/sequelae of multiple concussion and RHI exposure among athletes has been difficult to determine. Across three exposure paradigms (i.
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