AI Article Synopsis
- - The human cytomegalovirus (HCMV) ORF94 gene is expressed during both active infection and when the virus is dormant, but its role was previously unknown.
- - Researchers found that the ORF94 protein (pORF94) reduces the expression and activity of 2',5'-oligoadenylate synthetase (OAS), which is important for the antiviral response in cells.
- - This study is the first to identify a specific function for pORF94, highlighting how HCMV may weaken the host's antiviral defenses during active infection.
Article Abstract
The human cytomegalovirus (HCMV) ORF94 gene product has been reported to be expressed during both productive and latent phases of infection, although its function is unknown. We report that expression of pORF94 leads to decreased 2',5'-oligoadenylate synthetase (OAS) expression in transfected cells with and without interferon stimulation. Furthermore, the functional activity of OAS was inhibited by pORF94. Finally, we present evidence of OAS modulation by pORF94 during productive HCMV infection of human fibroblasts. This study provides the first identification of a function for pORF94 and identifies an additional means by which HCMV may limit a critical host cell antiviral response.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3094971 | PMC |
| http://dx.doi.org/10.1128/JVI.02463-10 | DOI Listing |
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