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Probabilistic graphical models for genetic association studies. | LitMetric

Probabilistic graphical models for genetic association studies.

Brief Bioinform

Ecole Polytechnique de l'Université de Nantes, rue Christian Pauc, BP 50609, 44306 Nantes Cedex 3, France.

Published: January 2012

AI Article Synopsis

Article Abstract

Probabilistic graphical models have been widely recognized as a powerful formalism in the bioinformatics field, especially in gene expression studies and linkage analysis. Although less well known in association genetics, many successful methods have recently emerged to dissect the genetic architecture of complex diseases. In this review article, we cover the applications of these models to the population association studies' context, such as linkage disequilibrium modeling, fine mapping and candidate gene studies, and genome-scale association studies. Significant breakthroughs of the corresponding methods are highlighted, but emphasis is also given to their current limitations, in particular, to the issue of scalability. Finally, we give promising directions for future research in this field.

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Source
http://dx.doi.org/10.1093/bib/bbr015DOI Listing

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