Background: Dementia and cognitive impairment are known to be risk factors for hip fractures and are associated with increased postoperative morbidity and mortality. Little is known of the prevalence of dementia and cognitive impairment among older adults with hip fractures.
Methods: We completed searches of the electronic databases for observational studies and report the prevalence of either dementia or cognitive impairment among individuals with hip fractures. We included studies that reported the prevalence of dementia using standard diagnostic criteria or cognitive impairment as measured on cognitive screening tests. We used random-effects meta-analysis to arrive at pooled estimates of the prevalence of dementia and cognitive impairment.
Results: Five studies reported the prevalence of dementia and 34 studies reported the prevalence of cognitive impairment in older adults with hip fractures. The estimated prevalence of dementia among older adults with hip fractures was 19.2% (95% confidence interval [CI]: 11.4% to 30.6%), whereas the prevalence of cognitive impairment was 41.8% (95% CI: 37.0% to 46.8%). In subgroup analyses, individuals admitted from long-term care were more likely to have dementia when compared with individuals admitted from the community, whereas there were no significant differences in the prevalence of cognitive impairment according to gender or study setting.
Conclusions: We conclude that dementia and cognitive impairment are common among older adults with hip fractures. Clinicians providing care for individuals with hip fractures should be aware of the high prevalence of cognitive impairment in this population. Effective strategies to prevent hip fractures and improve postoperative outcomes for older adults with dementia are needed.
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http://dx.doi.org/10.1016/j.jamda.2010.12.001 | DOI Listing |
BMC Psychiatry
January 2025
Department of Psychiatry, Makerere University College of Health Sciences, Kampala, Uganda.
BMC Prim Care
January 2025
Centre for Psychiatry and Mental Health, Wolfson Institute of Population Health, QMUL, London, UK.
Objective: As populations age globally, there is increasing prevalence of multiple long-term conditions, such as dementia, leading to many challenges. The burden on health and care services, economic pressures, and the necessity for innovative policies to better support older people and people with dementia becomes paramount. This review explores how clinical pharmacists working in UK primary care support older people and people with dementia.
View Article and Find Full Text PDFBiol Trace Elem Res
January 2025
Laboratory Functional Physiology and Bio-Resources Valorisation, Higher Institute of Biotechnology of Beja, University of Jendouba, Avenue Habib Bourguiba BP 382, 9000, Beja, Tunisia.
Iron overload has been shown to have deleterious effects in the brain through the formation of reactive oxygen species, which ultimately may contribute to neurodegenerative disorders. Accordingly, rodent studies have indicated that systemic administration of iron produces excess iron in the brain and results in behavioral and cognitive deficits. To what extent cognitive abilities are affected and which neurobiological mechanisms underlie those deficits remain to be more fully characterized.
View Article and Find Full Text PDFSci Rep
January 2025
Center for Cognitive Science, Cognitive and Developmental Psychology Unit, University of Kaiserslautern-Landau (RPTU), 67663, Kaiserslautern, Germany.
Short-term memory for sequences of verbal items such as written words is reliably impaired by task-irrelevant background sounds, a phenomenon known as the "Irrelevant Sound Effect" (ISE). Different theoretical accounts have been proposed to explain the mechanisms underlying the ISE. Some of these assume specific interference between obligatory sound processing and phonological or serial order representations generated during task performance, whereas other posit that background sounds involuntarily divert attention away from the focal task.
View Article and Find Full Text PDFPsychopharmacology (Berl)
January 2025
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Rationale: One of the most debilitating drawbacks of cisplatin chemotherapy is neurotoxicity which elicits memory impairment and cognitive dysfunction (chemobrain). This is primarily triggered by oxidative stress and inflammation. Captopril, an angiotensin-converting enzyme inhibitor, has been reported as a neuroprotective agent owing to its antioxidant and anti-inflammatory effects.
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