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J Adv Periodontol Implant Dent
September 2024
Department of Pharmaceutics, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
Background: Peri-implant diseases, such as peri-implant mucositis and peri-implantitis, are inflammatory conditions caused by biofilms that can lead to the loss of surrounding soft tissues and bone. The most effective treatment involves non-surgical mechanical debridement to remove plaque, but other treatment modalities have shown limited success. This study investigated the anti-inflammatory and immunomodulatory effects of atorvastatin (ATV) gel as an additional treatment for peri-implant mucositis.
View Article and Find Full Text PDFAdv Mater
December 2024
School of Biomedical Engineering, Sichuan University, Chengdu, 610065, China.
Stubborn biofilm infections pose serious threats to public health. Clinical practices highly rely on mechanical debridement and antibiotics, which often fail and lead to persistent and recurrent infections. The main culprits are 1) persistent bacteria reviving, colonizing, and rejuvenating biofilms, and 2) secondary pathogen exposure, particularly in individuals with chronic diseases.
View Article and Find Full Text PDFAdv Healthc Mater
December 2024
College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun, 130012, P. R. China.
Clin Infect Dis
December 2024
Department of Medical Microbiology and Infection Prevention, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Spinal implant infections are a serious complications of instrumented spinal fusion surgeries, carrying high morbidity and complex management challenges. Early postoperative infections may manifest with wound-healing issues, back pain, and fevers. Magnetic resonance imaging (MRI) is the preferred imaging modality, but can be limited by metal artifacts.
View Article and Find Full Text PDFJ Orthop Trauma
December 2024
Department of Orthopaedic Surgery, University of Missouri, Columbia, MO, USA.
Introduction: Acute fracture-related infections are challenging problems, affecting up to 20% of orthopaedic trauma patients. High recurrence rates, secondary surgeries, and rehospitalizations lead to increased healthcare costs and are major burdens to patients. Bacteriophage therapy offers a potential alternative treatment option to address these challenges.
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