Aim: To study antiviral activity of extracts obtained from basidial fungi against influenza viruses of different subtypes.
Materials And Methods: Antiviral activity of extracts obtained from basidial fungi against influenza virus A/chicken/Kurgan/05/2005 (H5N1) was determined in in vitro experiments. Changes in infectiousness of pandemic influenza virus A/Moscow/226/2009 (HIN1)v caused by extracts of basidial fungi was studied in experiments in vitro and in vivo.
Results: Seventy water extracts of basidial fungi were studied, of which 10 were able to inhibit infectiousness of influenza virus strain A/ chicken/Kurgan/05/2005 (H5N1) in MDCK cell culture. Also, several studied extracts decreased infectiousness of pandemic influenza virus strain A/ Moscow/226/2009 (H1N1)v in MDCK cells and inhibit its reproduction in lungs of infected mice.
Conclusion: High antiviral activity of extracts obtained from basidial fungi against influenza viruses opens perspectives for development of drugs with preventive and treatment effects.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Antibacterial and Antifungal Activity of Metabolites from Basidiomycetes: A Review.
Antibiotics (Basel)
October 2024
FSBI Gause Institute of New Antibiotics, Bol'shaya Pirogovskaya Str., 11, 119021 Moscow, Russia.
: The search for new antimicrobial molecules is important to expand the range of available drugs, as well as to overcome the drug resistance of pathogens. One of the promising sources of antibacterial and antifungal metabolites is basidial fungi, which have wide biosynthetic capabilities. : The review summarized the results of studying the antimicrobial activity of extracts and metabolites from basidiomycetes published from 2018-2023.
View Article and Find Full Text PDFIntroduction: The COVID-19 pandemic combined with seasonal epidemics of respiratory viral diseases requires targeted antiviral prophylaxis with restorative and immunostimulant drugs. The compounds of natural origin are low-toxic, but active against several viruses at the same time. One of the most famous compounds is Inonotus obliquus aqueous extract.
View Article and Find Full Text PDFAntitumor Properties of Aqueous Extracts from Inonotus rheades Mycelium and Their Evaluation under Various Cultivation Conditions.
Dokl Biochem Biophys
August 2022
Irkutsk Scientific Center for Surgery and Traumatology, Irkutsk, Russia.
The antitumor properties of aqueous extracts of Inonotus rheades basidiomycete mushrooms were evaluated when the fungi were cultured on wood discs and wood shavings (birch) at 25 ± 1°C in the dark and under constant illumination with blue light (12.8 W/m). The aqueous fraction containing water-soluble polysaccharides was isolated and analyzed: WS-5 fraction cultured on wood discs under blue light illumination, WS-8 fraction grown under similar conditions on wood shavings; WS-6 fraction grown in the dark on wood discs; and WS-7 fraction grown under similar conditions on wood shavings.
View Article and Find Full Text PDFThe effects of a number of culture medium components, such as peptone, yeast extract, mono- and disaccharides, copper ions, 2,6-dimethylphenol, and polycaproamide fiber, on the laccase activity dynamics in the culture liquid and laccase isoform production by the Lentinus strigosus 1566 fungus were studied. It was demonstrated that some saccharides selectively induced or inhibited the synthesis of different laccase isoforms. Similar action was exerted by copper ions, 2,6-dimethylphenol, and polycaproamide fiber, as well as by their combination.
View Article and Find Full Text PDFAntiviral activity of polyporoid mushrooms (higher Basidiomycetes) from Altai Mountains (Russia).
Int J Med Mushrooms
April 2012
State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk region, Russia.
Antiviral activity against type A influenza virus of birds A/chicken/Kurgan/05/2005 (H5N1) and humans A/Aichi/2/68 (H3N2) was investigated for aqueous extracts from mycelium of 11 basidial fungi species collected in the Altai Mountains (Altai Republic, Russia). The most perspective strains for producing antiviral medicines are studied strains Daedaleopsis confragosa, Datronia mollis, Ischnoderma benzoinum, Trametes gibbosa, T. versicolor, Laricifomes officinalis, and Lenzites betulina.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!