Amphiphilic dendritic peptides: Synthesis and behavior as an organogelator and liquid crystal.

Beilstein J Org Chem

Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Ministry of Education, College of Chemistry and Environment Science, Hebei University, Baoding 071002, P.R. China.

Published: February 2011

New amphiphilic dendritic peptides on dendritic polyaspartic acid were designed and synthesized. The organogel and liquid crystal properties of these amphiphilic dendritic peptides were fully studied by field-emission SEM, temperature dependent FT-IR, differential scanning calorimetry, polarization optical microscopy and X-ray diffraction experiments. Amphiphilic dendritic peptides G3 show good organogel properties with a minimum gelation concentration as low as 1 wt %. Furthermore, amphiphilic dendritic peptides G3 can form a hexagonal columnar liquid crystal assembly over a wide temperature range.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063067PMC
http://dx.doi.org/10.3762/bjoc.7.26DOI Listing

Publication Analysis

Top Keywords

amphiphilic dendritic
20
dendritic peptides
20
liquid crystal
12
amphiphilic
5
peptides
5
dendritic
5
peptides synthesis
4
synthesis behavior
4
behavior organogelator
4
organogelator liquid
4

Similar Publications

This perspective begins with an overview of the major impact that the dendron, dendrimer, and dendritic state (DDDS) discovery has made on traditional polymer science. The entire DDDS technology is underpinned by an unprecedented new polymerization strategy referred to as step-growth, amplification-controlled polymerization (SGACP). This new SGACP paradigm allows for routine polymerization of common monomers and organic materials into precise monodispersed, dendritic macromolecules (i.

View Article and Find Full Text PDF

Osteosarcoma-targeting Pt prodrug amphiphile for enhanced chemo-immunotherapy via Ca trapping.

Acta Biomater

December 2024

Department of Pharmaceutics, School of Pharmacy, Qingdao University, Qingdao 266021, China. Electronic address:

Platinum (Pt)-based anticancer agents exhibit a lack of selectivity in the treatment of osteosarcoma, resulting in significant toxicity. Furthermore, immune surveillance withinthe tumor microenvironment impedes the uptake of platinum drugs by osteosarcoma cells. To overcome these challenges, an oxaliplatin-based Pt prodrug amphiphile (Lipo-OXA-ALN) was designed and synthesized by incorporatingan osteosarcoma-targeting alendronate (ALN) alongside a lipid tail.

View Article and Find Full Text PDF

Micellar "Click" Nanoreactors: Spiking Pluronic-Based Micelles with Polymeric Ligands.

Macromolecules

November 2024

Department of Organic Chemistry, School of Chemistry, Faculty of Exact Sciences, Tel-Aviv University, Tel- Aviv 6997801, Israel.

In recent years, the development of nanoreactors, such as micellar nanoreactors (MNRs) for catalytic transformations, has gained significant attention due to their potential in enhancing reaction rates, selectivity, efficiency, and, as importantly, the ability to conduct organic chemistry in aqueous solutions. Among these, the copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction represents a pivotal transformation and is widely used in the synthesis of bioconjugates, pharmaceuticals, and advanced materials. This study aims toward advancing our understanding of the design and utilization of polymeric amphiphiles containing tris-triazole ligands as an integral element for CuAAC reactions within MNRs.

View Article and Find Full Text PDF

Supramolecular Chiral Assembly of Dendritic Amphiphiles in Aqueous Media.

Chemistry

January 2025

International Joint Laboratory of Biomimetic & Smart Polymers, School of Materials Science and Engineering, Shanghai University, Mailbox 152, Shangda Rd. 99, Shanghai, 200444, China.

Dendritic amphiphiles are a promising class of topological blocks for self-assembly to construct chiral supramolecular aggregates in aqueous media. Their unique dendritic geometry, structure variability and multivalence can mediate the assemblies with versatile morphologies and functions. The bulky dendritic moieties also enable the appropriate association-repulsion balance to control supramolecular growth, and simultaneously shield the assemblies with enhanced stabilities.

View Article and Find Full Text PDF

Dual-Targeted Assembled Nanodrugs for Near-Infrared Photothermal Immunotherapy of Triple-Negative Breast Cancer.

ACS Appl Mater Interfaces

December 2024

State Key Laboratory of Biochemical Engineering, Key Laboratory of Biopharmaceutical Preparation and Delivery, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China.

Triple-negative breast cancer (TNBC) is known for its poor prognosis and aggressive behavior, being highly prone to recurrence and metastasis, and currently has limited effective treatment options. Photothermal therapy (PTT) is an emerging, minimally invasive, low-drug-resistance, and precisely controllable therapeutic method for cancer treatment, offering hope to break through the bottleneck in TNBC therapy. The antitumor efficiency of PTT is predominantly contingent upon the performance of the photothermal drugs.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!