The sulphilimine cross-link of the Goodpasture (GP) autoantigen is a novel molecular mechanism (structural constraint) for conferring immune privilege to a site which otherwise is susceptible to structural changes that induce an immunogenic and pathogenic conformation. Perturbation of the assembly or cleavage of the sulphilimine cross-links could be a key factor in the aetiology of Goodpasture's disease in susceptible individuals.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3095855 | PMC |
| http://dx.doi.org/10.1111/j.1365-2249.2011.04356.x | DOI Listing |
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