The combination of a ferrocenyl moiety with BAPTA provides a novel, water-soluble, redox-active chelator. This chelator behaving as a conformational sensor exhibits an unexpected electrochemical response with high affinity and selectivity for calcium.
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http://dx.doi.org/10.1039/c1cc11081k | DOI Listing |
Molecules
January 2025
Dipartimento di Chimica, Sapienza Università di Roma, P.le Aldo Moro 5, 00185 Rome, Italy.
The main categories of transition metal-mercury heterometallic compounds are briefly summarized. The attention is focused on complexes and clusters where the {Hg-Y} fragment, where Y represents a halide atom, interacts with transition metals. Most of the structurally characterized derivatives are organometallic compounds where the transition metals belong to the Groups 6, 8, 9 and 10.
View Article and Find Full Text PDFBMC Cancer
January 2025
Department of Biochemistry, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Background: Inadequate treatment responses, chemotherapy resistance, significant heterogeneity, and lengthy treatment durations create an urgent need for new pancreatic cancer therapies. This study aims to investigate the effectiveness of gemcitabine-loaded nanoparticles enclosed in an organo-metallic framework under ketogenic conditions in inhibiting the growth of MIA-PaCa-2 cells.
Methods: Gemcitabine was encapsulated in Metal-organic frameworks (MOFs) and its morphology and size distribution were examined using transmission electron microscopy (TEM) and Dynamic light scattering (DLS) with further characterization including FTIR analysis.
Org Lett
January 2025
Department of Organic Chemistry, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012, P. R. China.
A Cu-catalyzed relay process for the preparation of diazidated quinazolinone and polycyclic imidazole derivatives in which readily available alkene-tethered substrates undergo an addition/cyclization/C(sp)-H functionalization of alkene sequences with high efficiency is described. Various functionalized N-heteropolycyclic compounds were readily prepared in good yields with a broad substrate scope. Moreover, the direct azidation of the α-C(sp)-H bond of the corresponding N-heterocycles has been demonstrated on the basis of mechanistic studies, which provide an alternative late-stage functionalization approach for the derivatization of N-heterocyclic scaffolds.
View Article and Find Full Text PDFChem Asian J
January 2025
Northwest University, College of Chemistry and Materials Science, 1 Xuefu Ave., Guodu Education and Hi-Tech Industries Zone, Chang'an District, 710127, Xi'an, CHINA.
The reversible photoisomerization of azobenzene (AZB) and its derivatives has been applied across various fields. Developing discrete AZB-functionalized organometallic cages is essential for manufacturing functional materials. In this work, we designed and fabricated a series of three-dimensional, hexaazobenzene-terminated poly-NHC-based (NHC = N-heterocyclic carbene) complexes [M3(A)2](BF4)3 and [M3(B)2](BF4)3 (M = Ag, Au).
View Article and Find Full Text PDFJ Am Chem Soc
January 2025
New Cornerstone Science Laboratory, State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China.
The asymmetric Tsuji-Trost reaction has been extensively studied due to its importance in establishing stereogenic centers, often adjacent to an -olefin moiety in organic molecules. The generally preferential formation of chiral -olefin products is believed to result from the thermodynamically more stable -π-allylpalladium intermediate. The rapid associative π-σ-π isomerization makes it challenging to synthesize chiral -olefin products via the transient -π-allylpalladium intermediate.
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