Five multidrug-resistant nonclonally related Enterobacteriaceae isolates were recovered in Belgium in 2010 from three patients who had been hospitalized in Pakistan, Montenegro, and Serbia/Kosovo. New Delhi metallo-β-lactamase (NDM-1) was detected in each of the isolates in addition to several extended-spectrum β-lactamases (CTX-M-15, SHV-12), plasmidic cephalosporinases (CMY-16, CMY-58), rRNA methylases (ArmA, RmtB), and Qnr genes (qnrA6, qnrB1, qnrB2). One patient died from uncontrolled sepsis, while the two others recovered. No secondary cases occurred in any of the hospitals.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101394PMC
http://dx.doi.org/10.1128/AAC.00049-11DOI Listing

Publication Analysis

Top Keywords

emergence ndm-1-producing
4
ndm-1-producing enterobacteriaceae
4
enterobacteriaceae belgium
4
belgium multidrug-resistant
4
multidrug-resistant nonclonally
4
nonclonally enterobacteriaceae
4
enterobacteriaceae isolates
4
isolates recovered
4
recovered belgium
4
belgium 2010
4

Similar Publications

Emergence of NDM-1-Producing Nosocomial Isolates in Attica Region of Greece.

Microorganisms

August 2024

AMR and HAIs Laboratory, Central Public Health Laboratory, National Public Health Organization, Vari, 16672 Attica, Greece.

Here, we report on the emergence and spread of multidrug-resistant NDM-1-producing isolates from patients hospitalized in the Attica region, Greece, in 2022 to provide data on their resistome, their virulome, the genetic environment of , and their molecular epidemiology. A total of 17 carbapenem-resistant isolates identified as NDM-producers by immunochromatography at the hospital level were sent to the Central Public Health Laboratory, in the frame of the laboratory surveillance of carbapenem-resistant pathogens, for further characterization. The initial screening for genetic AMR determinants was carried out by PCR and the MDR Direct Flow Chip assay.

View Article and Find Full Text PDF
Article Synopsis
  • A strain named fxq was isolated from a cerebrospinal fluid sample of a patient with tentorial meningioma, showcasing resistance to carbapenems due to the presence of KPC and NDM carbapenemase genes.
  • Identification methods included the Phoenix 100 system, MALDI-TOF, and whole-genome sequencing, revealing that fxq is a novel sequence type (ST202) with specific plasmid characteristics.
  • The study highlights the significant stability and transferability of the resistance plasmids, marking the first report of this particular resistant strain in a clinical setting.
View Article and Find Full Text PDF
Article Synopsis
  • Public health is increasingly challenged by pathogenic microorganisms with new antimicrobial resistance, making identification difficult for emerging pathogens like NDM-1-producing strains.
  • A study documents Brazil's first case of a new ST418 strain, initially misidentified, which was accurately identified through ANI analyses and whole-genome sequencing.
  • The study found that the resistance gene was located on a 112 kb IncFIB plasmid, emphasizing the need for public health vigilance as this species may spread significant resistance genes.
View Article and Find Full Text PDF

Unlabelled: This study aimed to characterize carbapenem-resistant (CRAB) isolates from Jiangxi patients using whole-genome sequencing (WGS). We subjected 100 clinical CRAB strains isolated from the three local largest teaching hospitals to WGS and antimicrobial susceptibility testing. Molecular epidemiology was investigated using multilocus sequence typing, core genome multilocus typing, core genome single-nucleotide polymorphism phylogeny, and pulsed-field gel electrophoresis.

View Article and Find Full Text PDF

Emergence and genomic chion of Proteus mirabilis harboring bla in Korean companion dogs.

Vet Res

April 2024

Department of Infectious Disease, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea.

Article Synopsis
  • Proteus mirabilis is a common bacterium in the GI tract of humans and animals, but strains producing the NDM-1 enzyme are becoming a significant health threat.
  • The first NDM-1 producing P. mirabilis strain, LHPm1, was found in a dog living with humans and showed 20 antimicrobial resistance genes through whole-genome analysis.
  • The study revealed various genetic relationships among P. mirabilis strains, emphasizing the need for urgent monitoring and control measures using a "one health approach" that considers humans, animals, and the environment together.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!