AI Article Synopsis
- The study focuses on creating and testing biocidal ionic liquids (ILs) that combine cationic imidazolium or pyridinium with a β-lactam antibiotic for enhanced antibacterial effectiveness.
- In tests against bacteria like E. coli and Staphylococcus aureus, these ILs demonstrated significantly stronger antibacterial properties compared to their original compounds and traditional sodium ampicillin.
- Ampicillin-based ILs showed up to 43 times better antibacterial activity than sodium ampicillin, highlighting their potential for improved treatment options.
Article Abstract
We herein report the preparation and investigation of antibacterial activity of biocidal ionic liquids (ILs) consisting of cationic imidazolium or pyridinium and an anionic β-lactam antibiotic. The antibacterial properties were quantified by measuring the minimum inhibitory concentration and minimum bactericidal concentration against Escherichia coli O157:H7, Klebsiella pneumoniae, Staphylococcus aureus, and Enterococcus faecium. In general, the ILs had improved antibacterial activity than their parent materials, whether individually or in combination. In 83% of the experiments, the ampicillin ILs (Amp-ILs) had better antibacterial activities than their quaternary halide parent materials, whereas in 92% of the experiments, Amp-ILs outperformed the commercially available sodium ampicillin salt. Amp-ILs had up to 43 times improved antibacterial activity than sodium ampicillin. Overall, when normalized for ampicillin content, ILs had greater antimicrobial activity against E. coli O157:H7, K. pneumoniae, S. aureus, and E. faecium than sodium ampicillin alone.
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| http://dx.doi.org/10.1111/j.1747-0285.2011.01114.x | DOI Listing |
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