AI Article Synopsis
- First generation antibody drugs target cancer cells, inhibit growth signals, and trigger the body's immune defense.
- Second generation antibody drugs are combined with toxic agents that are activated once they enter the cancer cells.
- Trastuzumab is a leading first generation drug for breast cancer, and its derivative trastuzumab-DM1 is being tested as the first antibody-drug conjugate for the same cancer.
Article Abstract
First generation antibody drugs recognize the cancer cell, slow down the signaling of cell growth and activate the defense response. Second generation antibody drugs contain conjugated cytotoxic agents that are activated upon entry into the cancer cell. Trastuzumab has become established among the first generation antibody drugs utilized in breast cancer therapy, and its derivative trastuzumab-DM1 is the first antibody-drug conjugate currently in clinical trials for breast cancer. Trastuzumab acts as an antibody and transports into the cancer cell the cytotoxic agent DM1, which becomes activated there. Targeted cytotoxic drugs are under development for the treatment of many different types of cancer.
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