[Efficacy of new antiepileptic drugs and the next generation drugs].

Brain Nerve

Morikawa Clinic, Nichimaru Nagoya Buil, Shin-Sakae-cho, Naka-Ku, Nagoya-city, Aichi, Japan.

Published: April 2011

Recent development and success in the field of new antiepileptic drug treatment, has resulted in the commercialization of many new drugs. The efficacy of these drugs has been assessed in many countries. Despite the progress in USA and European countries, a time lag of approximately 10 years concerning these new drugs exists in Japan. Since 2000, the above mentioned new drugs have been commercially available and are used to treat many patients with refractory epileptic seizures and verify their efficacy as well in Japan. Induced pluripotent stem (iPS) cells, which were invented in Japan are expected to accelerate the invention of more effective antiepileptic drugs in the near future.

Download full-text PDF

Source

Publication Analysis

Top Keywords

antiepileptic drugs
8
drugs
6
[efficacy antiepileptic
4
drugs generation
4
generation drugs]
4
drugs] development
4
development success
4
success field
4
field antiepileptic
4
antiepileptic drug
4

Similar Publications

Sodium valproate enhances efficacy of NKG2D CAR-T cells against glioblastoma.

Front Immunol

January 2025

Guangdong Immune Cell Therapy Engineering and Technology Research Center, Center for Protein and Cell-based Drugs, Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.

Chimeric antigen receptor T-cell (CAR-T) therapies have shown promise in glioblastoma clinical studies, but responses remain inconsistent due to heterogeneous tumor antigen expression and immune evasion post-treatment. NKG2D CAR-T cells have demonstrated a favorable safety profile in patients with hematologic tumors, and showed robust antitumor efficacy in various xenograft models, including glioblastoma. However, malignant glioma cells evade immunological surveillance by reducing NKG2D ligands expression or cleavage.

View Article and Find Full Text PDF

Cannabidiol Ameliorates Doxorubicin-Induced Myocardial Injury via Activating Hippo Pathway.

Drug Des Devel Ther

January 2025

School of Basic Medicine, Jiamusi University, Jiamusi, Heilongjiang, 154000, People's Republic of China.

Background: Doxorubicin (DOX) is a chemotherapeutic agent widely used for cancer treatment and has non-negligible cardiotoxicity. Some previous studies have reported that cannabidiol (CBD) has cardioprotective effects. In this study, we evaluated the protective effects of CBD against DOX-induced cardiomyocyte injury, and explored the downstream molecular mechanism.

View Article and Find Full Text PDF

Hypersensitivity Reactions to Anticonvulsants.

Curr Allergy Asthma Rep

January 2025

Rochester Regional Health, Rochester, NY, USA.

Background: Antiepileptics are the mainstay of treatment for seizure management. Immediate and delayed hypersensitivity reactions associated with antiepileptics are common. It is important to differentiate between these reactions as management and prognosis varies.

View Article and Find Full Text PDF

Design, synthesis and structure-activity relationship of novel 1,2,4-triazolopyrimidin-5-one derivatives targeting GABA and Na1.2 with antiepileptic activity.

Eur J Med Chem

January 2025

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Xiannongtan Street, Xicheng district, Beijing, 100050, China. Electronic address:

A novel class of 7-phenyl-[1,2,4]triazol-5(4H)-one derivatives was designed and synthesized, and their in vivo anticonvulsant activities were evaluated using subcutaneous pentylenetetrazole (Sc-PTZ) and maximal electroshock (MES) tests. Compounds 3u, 4f and 4k exhibited significant anticonvulsant activities in the Sc-PTZ model with ED values of 23.7, 17.

View Article and Find Full Text PDF

A successful initial management of a penetrating head trauma in a rural district hospital: Case report.

Trauma Case Rep

February 2025

Faculty of Health Sciences, Comparative Anatomy and Experimental Histopathology and Surgery, Université des Montagnes, Bangangté, West Cameroon, Cameroon.

Penetrating head trauma is the most fatal form of head injury. Although many cases of penetrating head trauma have been reported in the literature, its management remains complex, requiring a multidisciplinary team, which makes it a challenge in district hospitals where human resources and technical equipment are limited. We aim to present a successful initial management of a case of penetrating head trauma in a rural district hospital before a transfer to a first category hospital.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!