Children's developmental problems vary, with some easier to identify than others. The accuracy of caregivers' initial identification of children's developmental problems is important in the timely treatment of those problems by medical professionals. In this study, we investigated the degree to which caregivers' initial identification of children's developmental problems matched the clinical assessment by a team of qualified professionals in a developmental assessment unit of a medical center in Taiwan. The practitioners included a pediatric neurologist, a psychiatrist, a psychologist, an occupational therapist, a physical therapist, and two speech therapists. Caregivers of 943 children (age range: 2-80 months; mean: 37.7 months) who visited the unit for a suspected developmental problem were interviewed about the chief problem that led to the caregivers bringing their children to the unit. The results showed high agreement in the global and the motor domains between the caregivers and the professionals, and low agreement in the cognitive and the speech/language domains. The agreement was significantly related to the caregivers' native origin and socioeconomic status index (SSI). Caregivers with a foreign origin (immigrant mothers) and low SSI were more likely to misidentify their children's problems. It is recommended that pediatric practitioners offer continuing education to caregivers, especially in the domains of cognitive and speech/language development.
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http://dx.doi.org/10.1016/j.ridd.2011.02.026 | DOI Listing |
Proc Natl Acad Sci U S A
January 2025
Computational Radiology Laboratory, Boston Children's Hospital, Boston, MA 02115.
This study presents the construction of a comprehensive spatiotemporal atlas of white matter tracts in the fetal brain for every gestational week between 23 and 36 wk using diffusion MRI (dMRI). Our research leverages data collected from fetal MRI scans, capturing the dynamic changes in the brain's architecture and microstructure during this critical period. The atlas includes 60 distinct white matter tracts, including commissural, projection, and association fibers.
View Article and Find Full Text PDFPLoS Negl Trop Dis
January 2025
DeWorm3 Project, Seattle, Washington, United States of America.
Background: Historically, soil-transmitted helminth (STH) control and prevention strategies have relied on mass drug administration efforts targeting preschool and school-aged children. While these efforts have succeeded in reducing morbidity associated with STH infection, recent modeling efforts have suggested that expanding intervention to treatment of the entire community could achieve transmission interruption in some settings. Testing the feasibility of such an approach requires large-scale clinical trials, such as the DeWorm3 cluster randomized trial.
View Article and Find Full Text PDFPLoS One
January 2025
Department of Developmental Psychology, University of Hamburg, Hamburg, Germany.
Children begin to manage their reputation around school-age, but it remains unclear when they start to explicitly reason about reputational strategies such as lying from a third-person perspective. The current study investigated whether 5- and 7-year-old children would explicitly predict reputational lying in the context of a third party interaction. Participants were told hypothetical stories and asked to predict whether a protagonist would lie to a peer character about a selfish resource allocation.
View Article and Find Full Text PDFMedicine (Baltimore)
January 2025
Epilepsy Center, Children's Hospital Affiliated to Shandong University, Jinan, China.
Rationale: Developmental and epileptic encephalopathy (DEE) defines a group of severe and heterogeneous neurodevelopmental disorders. The voltage-gated potassium channel subfamily 2 voltage-gated potassium channel α subunit encoded by the KCNB1 gene is essential for neuronal excitability. Previous studies have shown that KCNB1 variants can cause DEE.
View Article and Find Full Text PDFSci Adv
January 2025
Department of Medical Genetics, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
Protein translation is crucial for fear extinction, a process vital for adaptive behavior and mental health, yet the underlying cell-specific mechanisms remain elusive. Using a Tet-On 3G genetic approach, we achieved precise temporal control over protein translation in the infralimbic medial prefrontal cortex () during fear extinction. In addition, our results reveal that the disruption of cytoplasmic polyadenylation element binding protein 1 (Cpeb1) leads to notable alterations in cell type-specific translational programs, thereby affecting fear extinction.
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