The anti-inflammatory effects of D-allose contribute to attenuation of cerebral ischemia-reperfusion injury.

It has been proved that multiple independently lethal mechanisms are involved in cerebral ischemia-reperfusion injury. Inflammatory processes, mediated by activated leukocytes, have been implicated in the mechanisms of cerebral ischemia-reperfusion injury. In addition, the leukocytes accumulated in the perivascular areas during the inflammatory responses after reperfusion will transform oxygen to reactive free radicals, release cytotoxic products and vasoactive substances, which further promotes brain injury. So activated leukocytes play an important role in the pathophysiologic process of cerebral I/R injury. D-allose, a rare sugar produced from D-ribose, attracts increased attention from researchers in recent years. It has been proved that D-allose can produce inhibitory effects on activated leukocytes in liver, kidney and retina, including immunosuppressive effects, anti-inflammatory effects, as well as anti-oxyradical effects. Furthermore, recent research work of our colleagues has demonstrated that D-allose could attenuate cerebral I/R injury by anti-oxyradical effects. However, inflammatory responses play an important role in the mechanisms of cerebral I/R injury. So we hypothesize that D-allose might perform neuroprotection against cerebral ischemia-reperfusion injury by its anti-inflammatory effects.