AI Article Synopsis
- The process of rearranging antibodies in the immune system depends on a DNA editing enzyme called AID (Activation-Induced Cytidine Deaminase).
- Researchers have been trying to understand how B lymphocytes manage to use high levels of AID without causing random mutations throughout their DNA.
- Recent genome-wide studies and findings about co-factors that direct AID's activity have provided new insights into how B cells regulate AID to maintain genetic stability.
Article Abstract
Post-rearrangement diversification of the antibody repertoire relies on a DNA editing factor, the cytidine deaminase AID. How B lymphocytes avoid generalized mutagenesis while expressing high levels of AID remained a long-standing question. Genome-wide studies of AID targeting combined to the discovery of several co-factors controlling its recruitment and its local activity shed new light on this enigma.
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| http://dx.doi.org/10.1016/j.coi.2011.02.002 | DOI Listing |
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