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The presence of unknown polio engagement confirmed by electromyography and muscle testing.
J Rehabil Med
January 2025
Borås hospital, Region Västra Götaland, Borås, Sweden; Department of Rehabilitation medicine, Sahlgrenska University Hospital, Gothenburg, Sweden.
Objective: To evaluate the usefulness of electromyography at a polio clinic in identifying unperceived muscle denervation. Second, to compare people who perceived themselves as weak in 1 or both legs with those who did not.
Design: Cross-sectional study.
Total knee arthroplasty in patient with poliomyelitis sequelae: maintaining a recurvatum is associated with better mid-term functional results.
Arch Orthop Trauma Surg
December 2024
Department of Orthopaedic and Trauma Surgery, Raymond-Poincaré Hospital, APHP, Garches, France.
Purpose: Total knee arthroplasty (TKA) in patients with sequelae of poliomyelitis is a surgical challenge due to muscle weakness, bone deformities or post-polio syndrome (PPS). Few data exist to determine the factors contributing to poor functional results. This study aimed: (1) to describe a cohort of patients with poliomyelitis sequelae who underwent TKA; (2) to examine risk factors for poor functional outcome.
View Article and Find Full Text PDFAntisera-Neutralizing Capacity of a Highly Evolved Type 2 Vaccine-Derived Poliovirus from an Immunodeficient Patient.
Viruses
November 2024
Department of Industrial Transformation, Institute of Medical Biology, Chinese Academy of Medical Sciences, Peking Union Medical College, Kunming 650000, China.
Article Synopsis
- The serotype 2 oral poliovirus vaccine (OPV2) can revert and lead to vaccine-derived poliovirus, posing a threat to eradication efforts, especially in immunocompromised individuals.
- A study analyzed changes in specific amino acids within the virus's structure that affect its ability to be neutralized by immune serum from vaccinated individuals.
- The findings indicate that mutations in the virus significantly reduce the effectiveness of antibodies, highlighting the need for ongoing monitoring of immunocompromised populations and maintaining high vaccination rates in these communities.
From Transfusion Medicine to Vaccines: The Enduring Impact of Karl Landsteiner.
Cureus
August 2024
Community Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
Article Synopsis
- Karl Landsteiner, a Nobel Prize winner, discovered blood types by identifying agglutinating antibodies, leading to safer blood transfusions and saving millions of lives.
- His work replaced dangerous practices of using animal blood and random human donors.
- Landsteiner also played a crucial role in medical advancements by identifying the poliomyelitis microbe and contributing to the discovery of syphilis-causing microbes.
Monitoring the VDPV2 outbreak in Egypt during 2020-2021 highlights the crucial role of environmental surveillance and boosting immunization in combating Poliovirus.
BMC Infect Dis
August 2024
Department of Microbiology and Immunology, Faculty of Pharmacy, Organization of African Union, Ain Shams University, St. Abbassia, Cairo, 11566, Egypt.
Background: Poliovirus is a highly infectious enterovirus (EV) that primarily affects children and can lead to lifelong paralysis or even death. Vaccine-derived polioviruses (VDPVs) are a great threat since they are derived from the attenuated virus in the Oral Poliovirus Vaccine (OPV) and can mutate to a more virulent form. The purpose of this study was to identify VDPV serotype 2 through the year 2020-2021 via surveillance of sewage samples collected from different localities and governorates in Egypt and stool specimens from Acute Flaccid Paralysis (AFP) cases.
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