AI Article Synopsis
- Nail clippings have been widely used for diagnosing nail diseases, and a new method called nail plate biopsies (NPBs) can detect crystals in the subungual horn, including urate crystals associated with gout.
- Despite looking for fungi, two gout cases were histologically identified, highlighting the potential for NPBs to reveal subclinical conditions.
- This technique enables doctors to assess not just nail diseases but also broader systemic health issues through noninvasive analysis of nail structures.
Article Abstract
The rewarding use of nail clippings processed histologically for the diagnosis of some nail diseases is well established. A new application of the nail plate biopsies (NPBs) is the detection of crystals in the subungual horn. Besides other subungual crystals, urate crystals are heretofore undescribed. This presentation adds to the advantages of an NPB: the detection of some cases of gout on which urate crystals are extruded subclinically. While searching for fungi, 2 cases of gout were diagnosed histologically, aided by unstained thick sections. A history of gout was then confirmed. No tophi were noted in or near the nail field. Chasing for crystals opens the study of fluids that may exude or transude into nail structures, a kind of "nail window" into hematic or metabolic abnormalities. In sum, the abundance of cytologic and histologic findings in an NPB can expand the armamentarium of physicians to evaluate nail diseases and even systemic diseases in a noninvasive manner.
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| http://dx.doi.org/10.1097/DAD.0b013e3181fe4b86 | DOI Listing |
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