Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3050432 | PMC |
| http://dx.doi.org/10.1186/2042-4280-1-1 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Neoself-antigens are the primary target for autoreactive T cells in human lupus.
Cell
October 2024
Laboratory of Immunochemistry, World Premier International Immunology Frontier Research Centre, Osaka University, Osaka 565-0871, Japan; Department of Immunochemistry, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan; Center for advanced modalities and DDS, Osaka University, Osaka 565-0871, Japan; Center for Infectious Disease Education and Research, Osaka University, Osaka 565-0871, Japan. Electronic address:
Article Synopsis
- * Neoself-antigens, which are unusual self-targets, are presented on MHC-II when the invariant chain is absent, leading to the activation of autoreactive T cells in SLE.
- * Research shows that these neoself-reactive T cells expand in SLE patients and can be activated by cells reactivated by the Epstein-Barr virus, indicating a significant relationship between viral infections and the development of lupus.
Article Synopsis
- Accurate differentiation between donor-derived post-transplant lymphoproliferative disorder (PTLD) and relapsed recipient-derived lymphoproliferative disorder (LPD) is essential for effective treatment post-hematopoietic stem cell transplantation (HSCT).
- Traditional diagnostic methods often fall short, especially in cases involving Epstein-Barr virus (EBV)-positive LPDs with low tumor cell counts.
- The newly developed method utilizes sex chromosome fluorescence in situ hybridization and other techniques on a single tissue section, successfully enabling accurate diagnosis of difficult cases and preserving histological structure.
A Case of Lymphomatoid Granulomatosis in a Lymph Node with Unique Clinical and Histopathologic Features.
Am J Case Rep
August 2022
Department of Internal Medicine, Premier Health, Dayton, OH, USA.
BACKGROUND Lymphomatoid granulomatosis (LyG) is a rare lymphoproliferative disorder associated with Epstein-Barr virus (EBV) in which there is an infection of B cells and numerous reactive T cells. The lymphoproliferative disorder progresses to organ infiltration and resultant dysfunction of affected organs. Histologically, it is characterized by a triad of polymorphic lymphoid infiltrate, angiitis, and granulomatosis.
View Article and Find Full Text PDFSimultaneous Seroprevalence to , Cytomegalovirus and Rubella Virus in Childbearing Women from Western Romania.
Medicina (Kaunas)
September 2021
Department of Obstetrics-Gynecology and Neonatology, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania.
: , cytomegalovirus (CMV) and rubella virus, besides other agents, belong to a group named the TORCH complex. Research on the epidemiology of these agents in women is of particular interest, as primary infection during pregnancy could cause severe damage to the fetus. Women who had contracted infection before pregnancy develop IgG antibodies, so the fetus is protected in case of contact with the same agent.
View Article and Find Full Text PDFParvovirus B19 in kidney transplantation: key points and essential pitfalls to know.
Infect Dis (Lond)
June 2021
Nephrology, Dialysis, and Kidney Transplantation Unit, University Hospital Mohammed VI, Oujda, University Mohammed First, Oujda, Morocco.
Parvovirus B19 infection is s new viral threat in post-kidney transplantation. It is a viral infection often acquired from the donor, occurring in young transplant patients during the first post-kidney transplantation months, and with a non-specific clinico-biological picture. The hallmark symptom is regenerative anaemia which may be severe, requiring blood transfusion.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!