Severity: Warning
Message: file_get_contents(https://...@gmail.com&api_key=61f08fa0b96a73de8c900d749fcb997acc09&a=1): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
Filename: helpers/my_audit_helper.php
Line Number: 197
Backtrace:
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 197
Function: file_get_contents
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 271
Function: simplexml_load_file_from_url
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3145
Function: getPubMedXML
File: /var/www/html/application/controllers/Detail.php
Line: 575
Function: pubMedSearch_Global
File: /var/www/html/application/controllers/Detail.php
Line: 489
Function: pubMedGetRelatedKeyword
File: /var/www/html/index.php
Line: 316
Function: require_once
Repetitive administration of quinolinic acid (QUIN, 50 mg/kg) induced generalized seizures only in 11-12, but not in 2-3, or 5-6 day rat puppies. Behavioural patterns characterizing postnatal development were registered within 3 months. Hyperactivity, increased thresholds for nociceptive reaction, as well as a the impairment of memory and learning were found in rats treated with QUIN at the age of 5-6 days. Disturbances in postnatal development are presumably due to the sensitivity of the brain tissue to QUIN and to the critical period of development of the central nervous system. It is suggested that the syndrome of minimal brain disfunction may be related to accumulation of QUIN at critical periods in the development of the nervous system.
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