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Cardiovascular Effects of Splenomegaly and Splenectomy in Beta-Thalassemia Major.
Cureus
November 2024
Medicine, Peshawar Medical College, Peshawar, PAK.
Background Beta-thalassemia major is a genetic blood disease complicated by splenomegaly, and splenectomy is a standard therapy for this medical condition. Although splenectomy results not only in the improvement of the hematological status, the long-term consequences to the cardiovascular system are still questionable. Objective The aim of the study was to assess and compare the cardiovascular impact of splenomegaly and splenectomy in patients with beta-thalassemia major.
View Article and Find Full Text PDFMicrorna363-5p targets thrombospondin3 to regulate pathological cardiac remodeling.
Mol Cell Biochem
October 2024
Department of Pathology, Affiliated Hospital of Qingdao University, Qingdao, 266000, China.
Cardiac remodeling is an end-stage manifestation of multiple cardiovascular diseases, and microRNAs are involved in a variety of posttranscriptional regulatory processes. miR-363-5p targeting Thrombospondin3 (THBS3) has been shown to play an important regulatory role in vascular endothelial cells, but the roles of these two in cardiac remodeling are unknown. Firstly, we established an in vivo model of cardiac remodeling by transverse aortic narrow (TAC), and then we stimulated a human cardiomyocyte cell line (AC16) and a human cardiac fibroblast cell line (HCF) using 1 μmol/L angiotensin II (Ang II) to establish an in vitro model of cardiac hypertrophy and an in vitro model of myocardial fibrosis, respectively.
View Article and Find Full Text PDFMagnoflorine attenuates Ang II-induced cardiac remodeling via promoting AMPK-regulated autophagy.
Cardiovasc Diagn Ther
August 2024
Department of Medical, the First People's Hospital of Yongkang, Yongkang, China.
Background: Heart failure (HF) remains one of the most common events in the progression of hypertension. Magnoflorine (MNF) has been shown beneficial effects on the cardiovascular system. However, the action of MNF on angiotensin (Ang) II-induced cardiac remodeling and its underlying mechanisms have not yet been characterised.
View Article and Find Full Text PDFHemodialysis patients have signs of a chronic thrombotic burden.
BMC Nephrol
July 2024
Department of Public Health and Clinical Medicine, Umea University, Umea, Sweden.
Background: Cardiovascular diseases are the dominant cause of morbidity in hemodialysis (HD) patients. Unless sufficient anticoagulation is used during HD, clotting may appear. The objective was to investigate if levels of fibrin degradation products (D-dimer) were increased before and during HD.
View Article and Find Full Text PDFImpact of Elevated Fibroblast Growth Factor 23 (FGF23) on the Cardiovascular System: A Comprehensive Systematic Literature Review.
Cureus
May 2024
Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Fibroblast growth factors (FGF) are a type of cell signaling proteins that are mostly produced by macrophages. They are essential for a variety of biological activities involved in normal development. Fibroblast growth factor 23 (FGF23) is the newest and youngest member of the FGF endocrine subfamily, along with fibroblast growth factor 19 (FGF19) and fibroblast growth factor 21 (FGF21).
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