Severity: Warning
Message: file_get_contents(https://...@pubfacts.com&api_key=b8daa3ad693db53b1410957c26c9a51b4908&a=1): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
Filename: helpers/my_audit_helper.php
Line Number: 176
Backtrace:
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 176
Function: file_get_contents
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 250
Function: simplexml_load_file_from_url
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3122
Function: getPubMedXML
File: /var/www/html/application/controllers/Detail.php
Line: 575
Function: pubMedSearch_Global
File: /var/www/html/application/controllers/Detail.php
Line: 489
Function: pubMedGetRelatedKeyword
File: /var/www/html/index.php
Line: 316
Function: require_once
Background: The quinoxaline nucleus is a part of several antibiotics, such as echinomycin, levomycin and actinomycin, which are known to inhibit the growth of Gram-positive bacteria and are active against various transplantable tumors. Benzodiazepines are important classes of heterocycles that draw significant interest from the pharmaceutical industry because of their prominent therapeutic value, such as antiviral, antibacterial, anti-inflammatory, antiprotozoaval properties and also as kinase inhibitors. They have also been evaluated as anticancer, anthelmintic, antifungal and insecticidal agents.
Results & Conclusion: Quinoxalines, benzodiazepines and their fluorinated derivatives have been prepared in excellent yields from the corresponding diamines and diketones using gallium (III) triflate as an efficient and environmentally friendly catalyst, due to its stability, recyclability and minimal toxicity.
Download full-text PDF |
Source |
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http://dx.doi.org/10.4155/fmc.09.77 | DOI Listing |
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