AI Article Synopsis
- The text highlights the importance of natural product 'scaffolds' in the development of numerous approved drugs and drug candidates for various diseases.
- It reviews specific chemical structures that have led to a significant number of effective drugs and drug leads.
- The authors also point out that some of these compounds can serve as building blocks for further chemical synthesis or possess unexpected biological activities.
Article Abstract
Numerous 'scaffolds' that have been identified in natural product structures have led to very significant numbers of approved drugs and drug candidates for a multiplicity of diseases over the years. In this mini-review, we discuss the base scaffolds (chemical skeletons) that we feel have produced very significant numbers of agents as drugs or drug leads and, in a number of cases, compounds that can be used as chemical synthons or that present activities in biological areas that were not obvious from their earlier history.
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| http://dx.doi.org/10.4155/fmc.09.113 | DOI Listing |
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