AI Article Synopsis
- A new two-step method for synthesizing the natural pigment echinamine A has been created.
- The process involves initially condensing 2,3-dichloro-6-ethyl-7-hydroxy-1,4-naphthoquinone with sodium nitrite.
- This is followed by a reduction step to turn the intermediate compound into echinamine A.
Article Abstract
New convenient two-step synthesis of natural pigment echinamine A by the condensation of 2,3-dichloro-6-ethyl-7-hydroxy-1,4-naphthoquinone with sodium nitrite and subsequent reduction of intermediate 7-ethyl-2,5,6,8-tetrahydroxy-3-nitro-1,4-naphthoquinone has been developed.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Mechanistic study on the reductive elimination of (aryl)(fluoroaryl)palladium complexes: a key step in regiospecific dehydrogenative cross-coupling.
Dalton Trans
August 2024
Institute of Pure and Applied Sciences, University of Tsukuba 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8573, Japan.
Article Synopsis
- Cross-dehydrogenative coupling (CDC) reactions are highlighted as efficient methods for creating C-C bonds, with a recent focus on the selective reaction between naphthalene and fluorobenzene at the β-position.
- The unique selectivity is driven by the reductive elimination process, influenced by the steric effects of the naphthyl group and the electron-withdrawing nature of fluorobenzene.
- The findings indicate that regioselectivity in C-H functionalization of polycyclic aromatic hydrocarbons (PAHs) relies on the reductive elimination rather than the initial C-H cleavage, with variations in selectivity depending on the specific PAH structure.
Selective -functionalization of Arylhydrazines with Primary Alcohols and Acids under PPh/DDQ System.
J Org Chem
July 2024
Jiangxi Province Key Laboratory of Natural and Biomimetic Drugs Research, College of Chemistry and Materials, Jiangxi Normal University, Nanchang 330022, PR China.
We present a PPh/DDQ-mediated regiospecific selective -functionalization of arylhydrazines with primary benzylic alcohols and aryl carboxylic acids for the synthesis of -benzyl arylhydrazines and -acyl arylhydrazines, respectively. This metal- and base-free approach features very short reaction times (about 10 min), broad substrate scope, good functional group tolerance, and mild reaction conditions. Furthermore, -benzlated products have also been successfully applied to the concise synthesis of -substituted indoles and anticancer drug MDM2 inhibitor.
View Article and Find Full Text PDFQuantitative, Regiospecific, and Stereoselective Radical Ring-Opening Polymerization of Monosaccharide Cyclic Ketene Acetals.
J Am Chem Soc
February 2024
Department of Chemistry, Boston College, Chestnut Hill, Massachusetts 02467, United States.
Cyclic ketene acetals (CKAs) are among the most well-studied monomers for radical ring-opening polymerization (rROP). However, ring-retaining side reactions and low reactivities in homopolymerization and copolymerization remain significant challenges for the existing CKAs. Here, we report that a class of monosaccharide CKAs can be facilely prepared from a short and scalable synthetic route and can undergo quantitative, regiospecific, and stereoselective rROP.
View Article and Find Full Text PDFInfluence of Dietary Triacylglycerol Structure on the Accumulation of Docosahexaenoic Acid [22:6(n-3)] in Organs in a Short-Term Feeding Trial with Mildly Omega-3 Deficient Rats.
Mol Nutr Food Res
March 2024
Food Sciences, Department of Life Technologies, University of Turku, Turku, 20520, Finland.
Scope: To study the effect of positional distribution of docosahexaenoic acid (DHA) in dietary triacylglycerols (TAG) on the tissue fatty acid content and composition of mildly (n-3) deficient rats.
Methods And Results: In a 5-day feeding trial, mildly (n-3) deficient rats received 360 mg daily structured TAGs: sn-22:6(n-3)-18:0-18:0, sn-18:0-18:0-22:6(n-3), sn-18:0-22:6(n-3)-18:0, or tristearin. A fifth group receives standard (n-3) adequate feed AIN-93G from birth till the end of the trial.
Regioselective Glycosylation of Polyphenols by Family 1 Glycosyltransferases: Experiments and Simulations.
ACS Omega
December 2023
The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby DK-2800, Denmark.
Family 1 glycosyltransferases (GT1s, UGTs) form natural product glycosides with exquisite control over regio- and stereoselectivity, representing attractive biotechnological targets. However, regioselectivity cannot be predicted and large-scale activity assessment efforts of UGTs are commonly performed via mass spectrometry or indirect assays that are blind to regioselectivity. Here, we present a large high performance liquid chromatography screening discriminating between regioisomeric products of 40 diverse UGTs (28.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!