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Mendelian randomization analysis reveals causal effects of inflammatory bowel disease and autoimmune hyperthyroidism on diffuse large B-cell lymphoma risk.
Sci Rep
November 2024
Key Laboratory of Integrated Traditional Chinese and Western Medicine for Hematology, Health Commission of Shandong Province; Institute of Hematology, Shandong University of Traditional Chinese Medicine, Jinan, People's Republic of China.
Article Synopsis
- This study investigates the controversial link between autoimmune diseases (ADs) and the risk of developing diffuse large B-cell lymphoma (DLBCL) using Mendelian randomization methods.
- Researchers analyzed data from nine ADs and compared it with DLBCL cases, aiming to establish causal associations using genetic markers (SNPs).
- The findings indicated that inflammatory bowel disease and autoimmune hyperthyroidism significantly increase DLBCL risk, while other conditions like asthma and psoriasis showed no significant associations.
Autoimmune Diseases and Risk of Non-Hodgkin Lymphoma: A Mendelian Randomisation Study.
Cancer Med
November 2024
Yale Center for Perinatal, Pediatric, and Environmental Epidemiology, Yale School of Public Health, New Haven, Connecticut, USA.
Article Synopsis
- Non-Hodgkin lymphoma (NHL) is a prevalent type of blood cancer, and its causes remain largely unknown, though autoimmune diseases are suspected as potential risk factors.
- A study used Mendelian randomization to investigate the relationship between ten autoimmune diseases and NHL risk, utilizing data from various European ancestry cohorts.
- The results indicated that genetically predicted susceptibility to type 1 diabetes and sarcoidosis may lower NHL risk, while no significant association was found for the other eight autoimmune diseases; further research is needed to confirm these findings.
History and Familial Aggregation of Immune-Mediated Diseases in Sarcoidosis: A Register-Based Case-Control-Family Study.
Chest
November 2024
Clinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
Background: An autoimmune component in the cause of sarcoidosis has long been debated, but population-based data on the clustering of immune-mediated diseases (IMDs) and sarcoidosis in individuals and families suggestive of shared cause are limited.
Research Question: Do patients with a history of IMDs have a higher risk of sarcoidosis and do IMDs cluster in families with sarcoidosis?
Study Design And Methods: We conducted a case-control-family study (2001-2020). Patients with sarcoidosis (N = 14,146) were identified in the Swedish National Patient Register using a previously validated definition (≥ 2 International Classification of Diseases [ICD]-coded inpatient or outpatient visits).
The causal relationship between sarcoidosis and autoimmune diseases: a bidirectional Mendelian randomization study in FinnGen.
Front Immunol
May 2024
Department of Occupational Medicine and Toxicology, Clinical Center for Interstitial Lung Diseases, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Background: Sarcoidosis has been considered to be associated with many autoimmune diseases (ADs), but the cause-and-effect relationship between these two diseases has not been fully explored. Therefore, the objective of this study is to explore the possible genetic association between sarcoidosis and ADs.
Methods: We conducted a bidirectional Mendelian randomization (MR) study using genetic variants associated with ADs and sarcoidosis (4,041 cases and 371,255 controls) from the FinnGen study.
Causal influence of celiac disease on the risk of sarcoidosis: A Mendelian randomization study.
Medicine (Baltimore)
April 2024
Department of Rheumatology and Immunology, Chengdu Third People's Hospital, Chengdu, China.
Observational research shows a link between celiac disease (CeD) and sarcoidosis, but the causal link between CeD and sarcoidosis is still unknown. A two-sample Mendelian randomization (MR) study was conducted to ascertain the causal connection between the 2 disorders. In our two-sample MR analysis, we identified independent genetic variants associated with CeD using publicly accessible GWAS data from people of European ancestry.
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