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N-glycan shielded CUB domains of ADAMTS13 prevent binding of C-terminal antibodies in patients with immune-mediated TTP.
Blood Adv
January 2025
Sanquin, Amsterdam, Netherlands.
In Immune-mediated Thrombotic Thrombocytopenic Purpura (iTTP), patients develop antibodies against ADAMTS13. The majority of patients exhibit inhibitory anti-spacer antibodies. Non-inhibitory antibodies binding to the carboxy-terminal CUB domains have been suggested to enhance the clearance of ADAMTS13 in iTTP.
View Article and Find Full Text PDFOrthodontic retainers: are they all the same?
Dental Press J Orthod
January 2025
Federal University of Rio de Janeiro, School of Dentistry, Department of Orthodontics (Rio de Janeiro/RJ, Brazil).
Introduction: It is known that the stability of the results obtained with orthodontic treatment depends, in addition to the functional and aesthetic aspects, also on the adequate planning of the retention devices, the patient's compliance with this new phase, and the physiological changes that the human body experiences over the years, throughout the craniofacial aging process.
Objective: This article discusses the importance of the orthodontic retention phase and the influence of diagnosis, planning and execution of corrective treatment of malocclusions, in order to achieve the expected success.
Methods: Throughout the text, different types of retainers and approaches during this phase will be presented, with the aim of ensuring the stability of the results obtained after correcting problems in the vertical, transverse and anteroposterior directions.
Severe malocclusion and oral health-related quality of life in adolescents aged 12-15 years.
Dental Press J Orthod
January 2025
Paraíba State University, Dentistry Program (Campina Grande/PB, Brazil).
Introduction: Malocclusion is a public health problem. The evidence of its impact on quality of life is contradictory and requires further studies.
Objective: The aim of this study was to estimate the prevalence of severe malocclusion and its impact on oral health-related quality of life in schoolchildren aged 12-15 years.
The (dis)continuity of breastfeeding care in prison: perception of health professionals and managers.
Rev Gaucha Enferm
January 2025
Universidade Federal do Pará. Belém. Pará. Brasil.
Objective: to describe the perception of health professionals and managers in the prison system regarding the continuity of breastfeeding care for lactating women deprived of liberty.
Method: descriptive-exploratory research, qualitative approach, developed in a prison unit in Rio de Janeiro from December 2022 to January 2023. Interviewees: five health professionals and two managers.
Damage control resuscitation: how it's done and where we can improve. A view of the Brazilian reality according to trauma professionals.
Rev Col Bras Cir
January 2025
- School of Medical Sciences Orebro university, Department of Surgery - Orebro - OR - Suécia.
Introduction: Hemorrhage is the leading cause of preventable deaths in trauma patients, resulting in 1.5 million deaths annually worldwide. Traditional trauma assessment follows the ABC (airway, breathing, circulation) sequence; evidence suggests the CAB (circulation, airway, breathing) approach to maintain perfusion and prevent hypotension.
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