AI Article Synopsis
- The study found that subantimicrobial-dose doxycycline (SDD) reduced bone-resorption biomarkers in post-menopausal women with osteoporosis and periodontitis.
- Changes in serum bone biomarkers were linked to systemic bone mineral density (BMD) loss at the lumbar spine and femoral neck.
- Along with systemic BMD loss, the biomarkers were also associated with alveolar bone density and height loss, indicating the relationship between serum biomarkers and both types of bone loss.
Article Abstract
Unlabelled: We recently reported that subantimicrobial-dose doxycycline (SDD) significantly reduced serum bone-resorption biomarkers in subgroups of post-menopausal women. We hypothesize that changes in serum bone biomarkers are associated not only with systemic bone mineral density (BMD) changes, but also with alveolar bone changes over time. One hundred twenty-eight eligible post-menopausal women with periodontitis and systemic osteopenia were randomly assigned to receive SDD or placebo tablets twice daily for two years, adjunctive to periodontal maintenance. Sera were analyzed for bone biomarkers. As expected, two-year changes in a serum bone biomarker were significantly associated with systemic BMD loss at the lumbar spine (osteocalcin, bone-turnover biomarker, p = 0.0002) and femoral neck (osteocalcin p = 0.0025). Two-year changes in serum osteocalcin and serum pyridinoline-crosslink fragment of type I collagen (ICTP; bone-resorption biomarker) were also significantly associated with alveolar bone density loss (p < 0.0001) and alveolar bone height loss (p = 0.0008), respectively. Thus, we have shown that serum bone biomarkers are associated with not only systemic BMD loss, but with alveolar bone loss as well.
Clinical Trial Registration Information: Protocol registered at ClinicalTrials.gov, NCT00066027.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092793 | PMC |
| http://dx.doi.org/10.1177/0022034511402993 | DOI Listing |
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