Metabolomics for mitochondrial and cancer studies.

Biochim Biophys Acta

Department of Chemical and Biomolecular Engineering, Department of Bioengineering, Rice University, 6100 Main St, Houston, TX 77005, USA.

Published: June 2011

AI Article Synopsis

  • Metabolomics is a rapidly growing field that plays a significant role in cancer diagnosis, prognosis, and the identification of novel biomarkers and therapies.
  • There is an increasing demand for sensitive and affordable diagnostic tools, as well as effective therapies to predict patient responses in cancer treatment, which metabolomics could help address.
  • Recent advancements in metabolic flux analysis are bridging gaps between clinical research and the development of innovative cancer treatments, particularly in the context of personalized medicine.

Article Abstract

Metabolomics, a high-throughput global metabolite analysis, is a burgeoning field, and in recent times has shown substantial evidence to support its emerging role in cancer diagnosis, cancer recurrence, and prognosis, as well as its impact in identifying novel cancer biomarkers and developing cancer therapeutics. Newly evolving advances in disease diagnostics and therapy will further facilitate future growth in the field of metabolomics, especially in cancer, where there is a dire need for sensitive and more affordable diagnostic tools and an urgency to develop effective therapies and identify reliable biomarkers to predict accurately the response to a therapy. Here, we review the application of metabolomics in cancer and mitochondrial studies and its role in enabling the understanding of altered metabolism and malignant transformation during cancer growth and metastasis. The recent developments in the area of metabolic flux analysis may help to close the gap between clinical metabolomics research and the development of cancer metabolome. In the era of personalized medicine with more and more patient specific targeted therapies being used, we need reliable, dynamic, faster, and yet sensitive biomarkers both to track the disease and to develop and evolve therapies during the course of treatment. Recent advances in metabolomics along with the novel strategies to analyze, understand, and construct the metabolic pathways opens this window of opportunity in a very cost-effective manner.

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Source
http://dx.doi.org/10.1016/j.bbabio.2011.03.006DOI Listing

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