AI Article Synopsis
- Abnormal neocortex development is linked to cognitive issues and epilepsy, with rodent models frequently used to investigate these problems.
- C57BL/6J mice, a popular strain for various studies, show neocortical malformations, including molecular-layer heterotopia.
- The occurrence of this condition varies by mouse sex and vendor source, highlighting important considerations for researchers using this strain in brain-behavior studies.
Article Abstract
Abnormal development of the neocortex is often associated with cognitive deficits and epilepsy. Rodent models are widely used to study normal and abnormal cortical development and have revealed the roles of many important genetic and environmental factors. Interestingly, several inbred mouse strains commonly used in behavioral, anatomical, and/or physiological studies display neocortical malformations including C57BL/6J mice, which are among the most widely utilized mice. In the present report we describe the prevalence and cytoarchitecture of molecular-layer heterotopia in C57BL/6J mice and related strains obtained from three commercial vendors as well as mice bred in academic vivaria from founders obtained commercially. In particular, we found that the prevalence of molecular-layer heterotopia vaired according to the sex as well as the vendor-of-origin of the mouse. These data are relevant to the use of this strain as a mouse-model in the study of brain-behavior relationships.
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| http://dx.doi.org/10.1016/j.brainres.2011.03.026 | DOI Listing |
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