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Comorbidity of Histamine Intolerance and Polyvalent Allergy: A Case Report and Literature Review.

Healthcare (Basel)

January 2025

Department of Prevention of Environmental Hazards Allergology and Immunology, Medical University of Warsaw, 02-097 Warsaw, Poland.

Histamine intolerance is becoming a critical medical problem across numerous clinical specialties, due to the absence of a standardized diagnostic and therapeutic strategy to manage patients with a suspicion of or diagnosis of this condition. Histamine intolerance is a type of non-immune food hypersensitivity, characterized by heterogenous etiologies and a very broad range of symptoms. The condition is the result of an imbalance between the amount of histamine accumulated within the body and the body's systemic ability to degrade it.

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Human intestinal spirochaetosis is caused by the colonisation of the luminal membrane of the colon and rectum by anaerobic spirochaetes belonging to the genus Brachyspira. The common method used for its diagnosis is routine haematoxylin and eosin staining of colonic and rectal biopsy samples. The clinical spectrum of human intestinal spirochaetosis is heterogeneous, ranging from asymptomatic colonisation to symptoms such as chronic mucosal diarrhoea, rectal bleeding, and abdominal pain.

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18F-FDG PET/CT Versus 18F-FAPI PET/CT in Eosinophilic Liver Infiltration.

Clin Nucl Med

January 2025

From the Department of Nuclear Medicine, Guangzhou Institute of Cancer Research, the Affiliated Cancer Hospital, Guangzhou Medical University.

A 48-year-old man presented with upper abdominal discomfort for 10 days. Abdominal contrast-enhanced CT showed multiple abnormal enhanced masses in liver, suggesting a probability of malignancies. The patient was then enrolled in a clinical trial of comparison of 18F-FDG and 18F-FAPI PET/CT in hepatic lesions.

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Introduction: Melanoma arising in blue nevus (BN) is usually evident on histopathology. However, there are cases in the gray zone where neither morphology nor immunostains and molecular studies are conclusive.

Case Report: A 33-year-old man presented with greenish discoloration of the abdominal skin at birth.

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Eosinophilic gastroenteritis is an uncommon, chronic, immune-mediated condition characterized by eosinophilic infiltration that can affect any segment of the gastrointestinal tract. Clinical manifestations depend on the different layers of the intestinal wall affected, which also allows its classification into three subtypes (Klein classification) (1): mucosal, which presents with abdominal pain, diarrhea, or vomiting; muscular, with obstruction or perforation; and serosal, classically with ascites. Diagnosis requires the demonstration of tissue eosinophilia with compatible clinical manifestations, after excluding other causes of eosinophilia.

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