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Middle ear biofilm and sudden deafness - a light and transmission electron microscopy study.
Front Neurol
December 2024
Department of Surgical Sciences, Otorhinolaryngology and Head and Neck Surgery, Uppsala University, Uppsala, Sweden.
Background: There still exists controversy about whether the healthy human middle ear mucosa is sterile or if it may harbor a diverse microbiome. Considering the delicacy of the human round window membrane (RWM), different mechanisms may exist for avoiding inner ear pathogen invasion causing sensorineural deafness. We re-analyzed archival human RWMs using light and transmission electron microscopy after decalcification to determine if bacteria are present in clinically normal human middle ears.
View Article and Find Full Text PDFThe role of inflammasome dysregulation in obstructive and non-obstructive azoospermia: a comparative molecular analysis of blood, tissue, and seminal plasma.
Front Immunol
December 2024
Reproductive Immunology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Background: To address knowledge gaps, this study aimed to investigate the involvement of inflammasomes in the etiology of azoospermia. This study focused on the gene expression of key inflammasome components, including , and .
Methods: We analyzed gene expression in blood and testicular tissue from patients with obstructive azoospermia (OA) and non-obstructive azoospermia (NOA).
The hidden impact of GLP-1 receptor agonists on endometrial receptivity and implantation.
Acta Obstet Gynecol Scand
December 2024
Department of Gynecology and Reproductive Medicine, Karolinska University Hospital, Stockholm, Sweden.
Increasing infertility rates represent a growing medical challenge in modern societies resulting from a complex interplay of sociocultural trends, lifestyle factors, exposure to environmental toxins, and underlying health problems. Women's fertility is particularly vulnerable to these shifts. The obesogenic lifestyle not only accelerates weight gain, but also disrupts ovulation driving the rise in infertility.
View Article and Find Full Text PDFAsymptomatic nasopharyngeal carriage of multidrug resistant bacteria among children at University of Gondar Hospital Northwest Ethiopia Revealing Hidden Health Risks.
Sci Rep
November 2024
Department of Medical Microbiology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Gram-negative bacteria in the nasopharynx can eventually invade bacteria-limited sites and cause serious illnesses such as meningitis, otitis media, and pneumonia. However, data related to the carriage of these bacteria in children attending outpatient departments in the study area are limited. To assess nasopharyngeal carriage, antibiotic susceptibility patterns, and associated factors of gram-negative bacteria among children attending the outpatient department at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia.
View Article and Find Full Text PDFColo-salpingeal fistula: A rare case report.
Radiol Case Rep
December 2024
Advanced Diagnostic and Interventional Radiology Research Center (ADIR), Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
Article Synopsis
- Salpingo-enteric fistula is a rare condition that forms an abnormal connection between the fallopian tube and the intestine, potentially leading to infertility.
- A case involving a 40-year-old asymptomatic woman revealed bilateral hydrosalpinx during hysterosalpingography, with contrast leaking into the descending colon, indicating a possible fistula.
- This type of fistula may be an unnoticed cause of infertility and should be considered only after excluding other infertility factors.
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