We report the first example of selective Pd-catalyzed mono-α-arylation of acetone employing aryl chlorides, bromides, iodides, and tosylates. The use of appropriately designed P,N-ligands proved to be the key to controlling the reactivity and selectivity. The reaction affords good yields with substrates containing a range of functional groups at modest Pd loadings using Cs(2)CO(3) as the base and employing acetone as both a reagent and the solvent.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/ja200009c | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Determination of antibacterial and antioxidant potential of organic crude extracts from Malus domestica, Cinnamomum verum and Trachyspermum ammi.
Sci Rep
January 2025
Department of Research and Development, Paktex Industries, 2.5 KM Tatlay Road, Kamoke, Gujranwala, 52470, Pakistan.
Plants are the rich source of biologically active compounds which can be obliging against various pathogenic microorganisms and cancerous diseases. The current study evaluated the antibacterial potential of aqueous, methanol, ethanol, and acetone extracts of Malus domestica (apple), Cinnamomum verum (cinnamon) and Trachyspermum ammi (ajwain) via agar well diffusion methods and minimum inhibitory concentration (MIC) in (mm) against Staphylococcus aureus (ATCC 25923) and Salmonella typhi (ATCC 19430). The antioxidant properties including total phenolic content (TPC), total flavonoid content (TFC), DPPH and reducing power was determined by UV/VIS spectrophotometery and all the results interpreted through one way ANOVA (STATISTICA).
View Article and Find Full Text PDFAssembly of oleosin during efficient extraction: Altering the sequence of defatting solvents.
Food Chem X
January 2025
Department of Food Science, Rutgers University, 65 Dudley Road, New Brunswick, NJ 08901, USA.
During the extraction of membrane proteins from oil bodies (OBs), organic solvents dissolve the lipid core and precipitate proteins through solvent stress. Here the effects of solvent type and defatting sequence on the composition and structure of membrane proteins were investigated SDS-PAGE, FTIR, and SEM-EDS. High purity oleosin (86 %) was obtained by treatment first with a Floch solution and then with cold acetone and petroleum ether after twice washing OBs with urea.
View Article and Find Full Text PDFBoosting Gaseous Acetone Detection by Nanoheterojunctions of p-Type MWCNTs/PANI Integrated into 3D Flame-Synthesized n-Type ZnO.
ACS Sens
January 2025
Dipartimento di Chimica, Università degli Studi di Milano, Golgi 19, 20133 Milan, Italy.
Accurate methods for detecting volatile organic compounds (VOCs) are essential for noninvasive disease diagnosis, with breath analysis providing a simpler, user-friendly alternative to traditional diagnostic tools. However, challenges remain in low-temperature VOC solid-state sensors, especially concerning their selectivity and functionality at room temperature. Herein, we present key insights into optimizing multiwalled carbon nanotubes (MWCNTs)/polyaniline (PANI) and ZnO nanocomposites for efficient, light-free selective acetone sensing.
View Article and Find Full Text PDFEnhanced butanol tolerance and production from puerariae slag hydrolysate by Clostridium beijerinckii through metabolic engineering and process regulation strategies.
Bioresour Technol
January 2025
College of Bioscience and Bioengineering, Institute of Applied Microbiology, Jiangxi Agricultural University, Nanchang, Jiangxi 330045, China. Electronic address:
Butanol is a more desirable second-generation biomass energy source. Acetone-butanol-ethanol (ABE) fermentation using Clostridium spp. is a promising method for butanol production.
View Article and Find Full Text PDFLeveraging Engineered Minicells for Bioconversion of Organic Acids into Short-Chain Methyl Ketones.
ACS Synth Biol
January 2025
The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, 2800, Denmark.
Methyl ketones, key building blocks widely used in diverse industrial applications, largely depend on oil-derived chemical methods for their production. Here, we investigated biobased production alternatives for short-chain ketones, adapting the solvent-tolerant soil bacterium as a host for ketone biosynthesis either by whole-cell biocatalysis or using engineered minicells, chromosome-free bacterial vesicles. Organic acids (acetate, propanoate and butanoate) were selected as the main carbon substrate to drive the biosynthesis of acetone, butanone and 2-pentanone.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!