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Basic Science and Pathogenesis.
Alzheimers Dement
December 2024
Michigan State University, Grand Rapids, MI, USA.
Background: A recent study of familial Alzheimer's disease identified a mutation in the RELN gene that appeared to delay the onset of dementia. It was hypothesized that this RELN-COLBOS variant protected against dementia by enhanced signaling at reelin receptors. We previously developed a secreted, bio-active reelin fragment (R36) and packaged it into AAV.
View Article and Find Full Text PDFDo specific myelin autoantibodies and increased cerebral dopamine neurotrophic factor in the context of inflammation predict the diagnosis of attention deficit hyperactivity disorder in medication-free children?
Brain Behav Immun
November 2024
Department of Radiology, Konya City Hospital, Karatay-Konya 42020, Turkey. Electronic address:
Article Synopsis
- The study examined the serum levels of various proteins related to myelin and inflammation in children with ADHD compared to healthy controls, focusing on their connection to clinical severity and irritability.
- Researchers included 141 ADHD children aged 8-14 and 135 typical controls, measuring protein levels using specific assays and assessing behaviors with standardized scales.
- Results indicated significantly higher levels of certain proteins (MAG, CDNF, hs-CRP, reelin, cerebellin) in ADHD children, alongside increased irritability, and noted significant correlations between some protein levels and clinical symptoms of ADHD and related disorders.
Upregulation of olfactory receptors and neuronal-associated genes highlights complex immune and neuronal dysregulation in Long COVID patients.
Brain Behav Immun
November 2024
Mike Petryk School of Dentistry, Division of Foundational Sciences, University of Alberta, Edmonton T6G 2E1, AB, Canada; Li Ka Shing Institute of Virology, University of Alberta, Edmonton T6G 2E1, AB, Canada; Women and Children Health Research Institute, University of Alberta, Edmonton T6G 2E1, AB, Canada; Cancer Research Institute of Northern Alberta, University of Alberta, Edmonton T6G 2E1, AB, Canada; Glycomics Institute of Alberta, Faculty of Medicine and Dentistry, University of Alberta, Edmonton T6G 2E1, AB, Canada. Electronic address:
A substantial portion of patients infected with SARS-CoV-2 experience prolonged complications, known as Long COVID (LC). A subset of these patients exhibits the most debilitating symptoms, similar to those defined in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). We performed bulk RNA sequencing (RNAseq) on the whole blood of LC with ME/CFS, at least 12 months post-onset of the acute disease, and compared them with controls.
View Article and Find Full Text PDFHeterogeneity in the formation of primary and secondary visual fields during human prenatal development.
Biol Res
November 2024
Avsyn Research Institute of Human Morphology of Federal State Budgetary Scientific Institution "Petrovsky National Research Centre of Surgery", Tsurupi Street, 3, Moscow, 117418, Russia.
The human neocortex has a huge surface area with unique cytoarchitectonics, most of which is concealed in sulci. Some cytoarchitectonic fields are associated with macroscopic landmarks. In particular, the primary visual field 17 is associated with the calcarine sulcus.
View Article and Find Full Text PDFThe Zebrafish Cerebellar Neural Circuits Are Involved in Orienting Behavior.
eNeuro
October 2024
Department of Biological Science, Graduate School of Science, Nagoya University, Nagoya, Aichi 464-8602, Japan
Deficits in social behavior are found in neurodevelopmental disorders, including autism spectrum disorders (ASDs). Since abnormalities in cerebellar morphology and function are observed in ASD patients, the cerebellum is thought to play a role in social behavior. However, it remains unknown whether the cerebellum is involved in social behavior in other animals and how cerebellar circuits control social behavior.
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