Evaluation of Aβ fibrillization inhibitory effect by a PEG-peptide conjugate based on an Aβ peptide fragment with intramolecular FRET.

Chem Commun (Camb)

Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University, 4-101 Koyama-chou, Tottori 680-8552, Japan.

Published: April 2011

A PEG-peptide conjugate based on an amyloid β peptide fragment was synthesized. The formed amyloid protofibril-like aggregates induced intramolecular FRET. It proved to be useful as a bioprobe to evaluate the inhibitory effect of organic molecules toward amyloid fibrillization.

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http://dx.doi.org/10.1039/c0cc05668eDOI Listing

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