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In celebration of its 50th year in publication, The Nurse Practitioner has asked 50 influential NPs for their thoughts on topics of import to the profession and its future, to be published in select months throughout the year. This month, five NPs share their wisdom on self-care, moral resilience, and career satisfaction.
View Article and Find Full Text PDFTailoring traditional Chinese medicine in cancer therapy.
Mol Cancer
January 2025
Department of Gynecology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310009, People's Republic of China.
Cancer remains a formidable global health challenge, necessitating innovative therapeutic approaches to enhance treatment efficacy and reduce adverse effects. The traditional Chinese medicine (TCM), as an embodiment of ancient wisdom, has been validated to regulate the holistic human capacity against both internal and external "evils" in accordance with TCM principles. Therefore, it stands to reason to integrate TCM into current cancer therapy paradigms, such as chemotherapy, immunotherapy, and targeted therapy.
View Article and Find Full Text PDFDIFLF: A domain-invariant features learning framework for single-source domain generalization in mammogram classification.
Comput Methods Programs Biomed
January 2025
School of Engineering Medicine, Beihang University, Beijing 100191, PR China; Key Laboratory of Big Data-Based Precision Medicine (Beihang University), Ministry of Industry and Information Technology of the People's Republic of China, Beijing 100191, PR China; Beijing Engineering Research Center of Cardiovascular Wisdom Diagnosis and Treatment, Beijing 100029, PR China. Electronic address:
Background And Objective: Single-source domain generalization (SSDG) aims to generalize a deep learning (DL) model trained on one source dataset to multiple unseen datasets. This is important for the clinical applications of DL-based models to breast cancer screening, wherein a DL-based model is commonly developed in an institute and then tested in other institutes. One challenge of SSDG is to alleviate the domain shifts using only one domain dataset.
View Article and Find Full Text PDFPerioperative changes in anxiety and comfort in third molar extraction patients sedated with midazolam.
Oral Maxillofac Surg
January 2025
Department of Oral and Maxillofacial Surgery, Nara Medical University, 840, Shijo-Cho, 634-8522, Kashihara, Nara, Japan.
Purpose: This study aimed to analyze changes in anxiety and comfort levels at each perioperative stage during third molar extraction under single-agent intravenous midazolam sedation, and to clarify how these conditions at each perioperative stage affect postoperative satisfaction.
Patients And Method: 115 who requested extraction of 1 ~ 4 third molars under single-agent intravenous midazolam sedation were targeted. These patients were administered a questionnaire survey one week after surgery.
From natural herbal wisdom to nano innovation: Revolutionizing tumor treatment through intervening in metabolic reprogramming.
Biochim Biophys Acta Rev Cancer
February 2025
Central Laboratory, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Jiangsu, Nanjing, China. Electronic address:
In recent years, with the deepening understanding of the biological mechanisms underlying tumorigenesis, metabolic reprogramming has emerged as a pivotal process in cancer initiation, progression, and treatment resistance, gradually paving the way for new avenues in precision oncology. Natural herbal ingredients, characterized by their multi-target engagement, low toxicity, and wide-ranging biological activities, exhibit unique advantages in anti-cancer therapy. Nonetheless, the clinical application of these components has been constrained by issues such as poor solubility, low bioavailability, and inadequate stability when administered through traditional delivery methods.
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