Severity: Warning
Message: file_get_contents(https://...@pubfacts.com&api_key=b8daa3ad693db53b1410957c26c9a51b4908&a=1): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
Filename: helpers/my_audit_helper.php
Line Number: 176
Backtrace:
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 176
Function: file_get_contents
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 250
Function: simplexml_load_file_from_url
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3122
Function: getPubMedXML
File: /var/www/html/application/controllers/Detail.php
Line: 575
Function: pubMedSearch_Global
File: /var/www/html/application/controllers/Detail.php
Line: 489
Function: pubMedGetRelatedKeyword
File: /var/www/html/index.php
Line: 316
Function: require_once
The verification of refined variants of already existing medicines proved to be a breakthrough for antibiotic research. However, resistance to old and newer antibiotics among microbacillary pathogens is evolving quickly. Drug-resistant pathogens have become an important economic burden for patients. This invention (WO2010080819) provides novel targeting moieties (peptides) that specifically/preferentially bind to microorganisms. The targeting moieties can be attached to effectors to form chimeric constructs for specifically/preferentially delivering the effector to and/or into the target organism. In certain embodiments, novel antimicrobial peptides that can be used to inhibit of certain microorganisms are provided.
Download full-text PDF |
Source |
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http://dx.doi.org/10.1517/13543776.2011.560571 | DOI Listing |
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