Venlafaxine is a newly introduced antidepressant that is clinically different from other antidepressants, possesses a slightly different mechanism of action and may have unique efficacy properties and a faster onset of action. A case of venlafaxine induced severe hypertension is reported to highlight the need for caution while using this drug.
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Environ Toxicol Chem
January 2025
School of Environment and Energy, South China University of Technology, Guangzhou, PR China.
As a representative agent of bicyclic antidepressants, venlafaxine (VEN) has become widely used worldwide and is frequently detected in surface waters with concentrations ranging from ng/L to µg/L. To evaluate the toxicological effects of such medications on aquatic species, studies on environmentally relevant concentrations are essential. Zebrafish were used as a model organism to assess growth and development in larvae and examine tissue accumulation, oxidative stress, and DNA methylation in adults.
View Article and Find Full Text PDFExpert Opin Drug Saf
December 2024
Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Background: Adverse cutaneous drug reactions have been reported with most drugs, including antidepressants (ADs) and second-generation antipsychotics (SGAs). The lack of extensive research on the relationship between ADs and SGAs, and cutaneous toxicity remains troubling. Our study aimed to assess the cutaneous toxicity of ADs and SGAs and provide valuable insights for clinical applications and scientific investigations.
View Article and Find Full Text PDFCNS Neurosci Ther
December 2024
Department of Urology, Second Hospital of Shanxi Medical University, Taiyuan, China.
Aim: Serotonin-norepinephrine reuptake inhibitors (SNRIs) have been extensively utilized for the treatment of depression and anxiety disorders. Clinical trials and real-world data suggest that SNRIs may cause reproductive toxicity. To comprehensively assess this association, we conducted a pharmacovigilance study.
View Article and Find Full Text PDFJ Pediatr Pharmacol Ther
December 2024
Department of Pharmacy (MO, GE-C), NYU Langone - Long Island, Department of Pediatrics (MC), NYU Langone - Long Island, Mineola, NY.
Maternal antidepressant use has increased during the past 2 decades, with venlafaxine emerging as a common agent during pregnancy. Both venlafaxine and its active metabolite possess prolonged half-lives in adults; however, abrupt discontinuation may lead to withdrawal including irritability, jitteriness, lethargy, restlessness, and insomnia. The drug and its metabolite readily cross the placenta, posing additional considerations during pregnancy.
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