The precise measurement of transition frequencies of trapped atomic samples is susceptible to inaccuracy arising from the inhomogeneous differential shift of the relevant energy levels in the presence of the trapping fields. We demonstrate near-complete cancellation of the differential ac Stark shift ("light shift") of a two-photon magnetic-field-insensitive microwave hyperfine (clock) transition in ^{87}Rb atoms trapped in an optical lattice. Up to 95(2)% of the differential light shift is cancelled while maintaining magnetic-field insensitivity. This technique should have applications in quantum information and frequency metrology.
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http://dx.doi.org/10.1103/PhysRevLett.106.063002 | DOI Listing |
Am J Clin Dermatol
January 2025
Department of Dermatology, The Ohio State University, 1328 Dublin Rd, Suite 100, Columbus, OH, 43212, USA.
Morbilliform eruptions, which are a clinical reaction pattern characterized by erythematous macules and papules coalescing into patches that cover most of the skin surface, are one of the most common cutaneous findings in the inpatient setting. In the hospital setting, most causes are benign and due to low-risk drug exanthems; however, morbilliform eruptions may also be a sign of high-risk diseases, including Stevens-Johnson syndrome/toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms/drug-induced hypersensitivity syndrome, acute generalized exanthematous pustulosis, and graft-versus-host disease. Proper identification of the etiology and risk stratification of a morbilliform eruption is critical to ensure proper management and optimize patient outcomes.
View Article and Find Full Text PDFStem Cell Rev Rep
January 2025
Dipartimento di Medicina Sperimentale, Università di Genova, Viale Benedetto XV, 3, Genova, 16132, Italy.
Progress of human brain in vitro models stands as a keystone in neurological and psychiatric research, addressing the limitations posed by species-specific differences in animal models. The generation of human neurons from induced pluripotent stem cells (iPSCs) using transcription factor reprogramming protocols has been shown to reduce heterogeneity and improve consistency across different stem cell lines. Despite notable advancements, the current protocols still exhibit several shortcomings.
View Article and Find Full Text PDFCancer Metastasis Rev
January 2025
Saliva and Liquid Biopsy Translational Laboratory, Institute for Biomedicine and Glycomics (IBG), Griffith University, Brisbane, 4111, Australia.
CT chest scans are commonly performed worldwide, either in routine clinical practice for a wide range of indications or as part of lung cancer screening programs. Many of these scans detect lung nodules, which are small, rounded opacities measuring 8-30 mm. While the concern about nodules is that they may represent early lung cancer, in screening programs, only 1% of such nodules turn out to be cancer.
View Article and Find Full Text PDFFish Physiol Biochem
January 2025
Centro Tlaxcala de Biología de La Conducta, Universidad Autónoma de Tlaxcala, 90070, Tlaxcala, Mexico.
Trophic factors, such as neurotrophins, are fundamental for cellular processes including differentiation, growth, survival, and regeneration. These molecules exhibit significant morphological and phylogenetic conservation throughout the animal kingdom, indicating conserved functions. In fish, the oldest and most diverse group of vertebrates, neurotrophins, and their receptors play pivotal roles not only within the central nervous system but also in various peripheral tissues.
View Article and Find Full Text PDFMol Biol Rep
January 2025
Department of Molecular Biology and Genetics, Faculty of Art and Science, Tokat Gaziosmanpasa University, Tokat, 60200, Türkiye.
Background: SARS-CoV-2 infection is marked by an excessive inflammatory response, leading to elevated production of pro-inflammatory cytokines through activation of intracellular pathways like mitogen-activated protein kinase (MAPK). Viruses can use the MAPK signaling pathway to their advantage, but the relationship of this pathway to the severe SARS-CoV-2 period has not been fully elucidated. MAP2K4 is involved in the MAPK signaling pathway and affects cellular processes such as cell-cell junction, cell proliferation, differentiation and apoptosis.
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