Elastic sheets with macroscopic dimensions are easy to deform by bending and stretching. Yet shaping nanometric sheets by mechanical manipulation is hard. Here we show that nanoparticle self-assembly could be used to this end. We demonstrate that spherical nanoparticles adhering to the outer surface of an elastic nanotube can self-assemble into linear structures: rings or helices on stretchable nanotubes, and axial strings on nanotubes with high rigidity to stretching. These self-assembled structures are inextricably linked to a variety of deformed nanotube profiles, which can be controlled by tuning the concentration of nanoparticles, the nanoparticle-nanotube diameter ratio and the elastic properties of the nanotube. Our results open the possibility of designing nanoparticle-laden tubular nanostructures with tailored shapes, for potential applications in materials science and nanomedicine.
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Bioact Mater
March 2025
Department of Plastic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, 3 East Qingchun Road, Hangzhou, 310016, China.
Achieving scar-free skin regeneration in clinical settings presents significant challenges. Key issues such as the imbalance in macrophage phenotype transition, delayed re-epithelialization, and excessive proliferation and differentiation of fibroblasts hinder wound healing and lead to fibrotic repair. To these, we developed an active shrinkage and antioxidative hydrogel with biomimetic mechanical functions (P&G@LMs) to reshape the healing microenvironment and effectively promote skin regeneration.
View Article and Find Full Text PDFInt J Mol Sci
November 2024
Gansu Key Laboratory of Herbivorous Animal Biotechnology, College of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China.
As an indigenous species on the Tibetan Plateau, the yak is well adapted to the plateau hypoxic environment. The high-altitude hypoxia adaptation of the yak requires the adaptive reshaping of multiple tissues and organs, especially the lungs. To reveal the adaptive development of yak lungs under hypoxic stress at the tissue and molecular levels, we conducted histomorphological observations as well as transcriptomic and metabolomic studies of yak lungs at three ages (0.
View Article and Find Full Text PDFNeural Netw
January 2025
Department of Mathematics, Indian Institute of Technology Indore, Simrol, Indore, 453552, Madhya Pradesh, India. Electronic address:
Support vector machine (SVM) is one of the most studied paradigms in the realm of machine learning for classification and regression problems. It relies on vectorized input data. However, a significant portion of the real-world data exists in matrix format, which is given as input to SVM by reshaping the matrices into vectors.
View Article and Find Full Text PDFSoft Matter
September 2024
Institut Charles Sadron UPR22-CNRS, 67034 Strasbourg, France.
Filamentous viruses like influenza and torovirus often display systematic bends and arcs of mysterious physical origin. We propose that such viruses undergo an instability from a cylindrically symmetric to a toroidally curved state. This "toro-elastic" state emerges spontaneous symmetry breaking under prestress due to short range spike protein interactions magnified by surface topography.
View Article and Find Full Text PDFBiomater Adv
October 2024
Department of Chemical and Materials Engineering, Faculty of Engineering, The University of Auckland, Auckland, New Zealand; The MacDiarmid Institute for Advanced Materials and Nanotechnology, Wellington, New Zealand. Electronic address:
In the field of tissue engineering, there is a growing need for biomaterials with structural properties that replicate the native characteristics of the extracellular matrix (ECM). It is important to include fibrous structures into ECM mimics, especially when constructing scar models. Additionally, including a dynamic aspect to cell-laden biomaterials is particularly interesting, since native ECM is constantly reshaped by cells.
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