To investigate the safety and efficacy of Adenoscan injection 60 mg (adenosine), a pharmacologic stress agent that can be used for coronary vasodilation in patients unable to exercise adequately, the drug use results survey was conducted by consecutive patients-survey method in 166 nationwide medical institutes from 2006 to 2008. Adverse drug reactions (ADRs) occurred at the rate of 16.0% (343/2,150 patients), most of which disappeared shortly with no need for treatment. Major ADRs were chest discomfort at the rate of 4.9%, chest pain 2.0%, atrioventricular block 1.8% and dyspnea 1.4%. There were no differences in the incidences of ADRs between the elderly and the non-elderly. The overall efficacy rate was 97.9% (2,104/2,150 patients) according to the efficacy judgment of each primary physician. The sensitivity, specificity and diagnostic accuracy of myocardial perfusion scintigraphy in 608 patients who underwent coronary angiography were 70.8%, 58.1% and 65.0%, respectively. We conclude that adenosine stress is safe and useful for myocardial perfusion scintigraphy to detect ischemic heart disease for patients who are unable to exercise adequately.
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