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Ferroptosis: when metabolism meets cell death.
Physiol Rev
December 2024
Institute of Metabolism and Cell Death, Molecular Targets and Therapeutics Center, Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany.
We present here a comprehensive update on recent advancements in the field of ferroptosis, with a particular emphasis on its metabolic underpinnings and physiological impacts. After briefly introducing landmark studies that have helped to shape the concept of ferroptosis as a distinct form of cell death, we critically evaluate the key metabolic determinants involved in its regulation. These include the metabolism of essential trace elements such as selenium and iron; amino acids such as cyst(e)ine, methionine, glutamine/glutamate and tryptophan; and carbohydrates, covering glycolysis, the citric acid cycle, the electron transport chain and the pentose phosphate pathway.
View Article and Find Full Text PDFHijacking host cell vesicular transport: New insights into the nutrient acquisition mechanism of .
Virulence
December 2024
Institute of Pathogenic Biology, Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control, Hengyang Medical School, University of South China, Hengyang, Hunan, P.R. China.
infection is an important cause of public health diseases, and no effective vaccine is currently available. Owing to its unique intracellular lifestyle, requires a variety of nutrients and substrates from host cells, particularly sphingomyelin, cholesterol, iron, amino acids, and the mannose-6-phosphate receptor, which are essential for inclusion development. Here, we summarize the recent advances in nutrient acquisition mechanism by hijacking host cell vesicular transport, which plays an important role in chlamydial growth and development.
View Article and Find Full Text PDFMyocardial Ischemia/Reperfusion Injury: Mechanism and Targeted Treatment for Ferroptosis.
Anatol J Cardiol
February 2024
School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Myocardial ischemia/reperfusion injury (MIRI) is a pathophysiological process connected to the onset of numerous heart disorders. The pathogenesis of MIRI is complex, and it mainly involves calcium overload, classic oxidative stress, mitochondrial disorder, inflammation, microvascular disorder, and cell death. The clinical treatment options for MIRI are presently constrained, making it imperative to develop new treatment modalities.
View Article and Find Full Text PDFRole and mechanism of ferroptosis in acute lung injury.
Cell Cycle
October 2023
Department of Pulmonary and Critical Care Medicine, First Affiliated Hospital, Kunming Medical University, Kunming, China.
Ferroptosis is a new non-apoptotic cell death caused by the accumulation of dysregulated metabolism of ferric iron, amino acids or lipid peroxidation. Increasing studies suggest that ferroptosis is involved in the acute lung injury (ALI). This article aims to review the role of ferroptosis in ALI.
View Article and Find Full Text PDFTargeting ferroptosis in renal cell carcinoma: Potential mechanisms and novel therapeutics.
Heliyon
August 2023
Department of Urology, Peking University First Hospital, Institute of Urology, National Research Center for Genitourinary Oncology, Peking University, Beijing, China.
Renal cell carcinoma (RCC) is an increasingly prevalent urologic malignancy that impacts human health worldwide. Surgery is an effective strategy for early RCC treatment, but advanced RCC is resistant to chemotherapy, thus development of other potential therapeutic strategies is urgent. Ferroptosis is a newly defined form of programmed cell death characterized by accumulation of iron-dependent lipid peroxides and plays a crucial role in the tumor progression and drug resistance.
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