Aim Of Study: We have assessed the influence of water restriction stress on the nitric oxide (NO) synthase in heart and aorta tissues in young 2-month-old and middle-aged 12-month-old rats.
Methods: Animals were divided into control and 24- and 72-h water-deprived groups. We evaluated systolic blood pressure (SBP), biochemical parameters, nitrate and nitrite urinary excretion (UNOx), NADPH-diaphorase activity, and protein levels of NOS in the right atria, left ventricle, and thoracic aorta tissues.
Results: Water restriction during 72 h increased SBP (16%) in 2-month-old rats but decreased it after 24 and 72 h (9 and 15%, respectively) in 12-month-old rats. Atria, aorta endothelium, and smooth muscle NOS activity increased (32, 63, and 88%, respectively) only after 72 h of water restriction in 2-month-old rats. It also increased not only after 72 h but also after 24 h in atria (27 and 18%, respectively) and in ventricle (39 and 67%, respectively) in 12-month-old rats. Meanwhile, in this group's aorta smooth muscle, the enzyme activity decreased (16 and 7%, respectively). A major difference seen between ages was the changes in UNOx excretion, which decreased in the younger in 24 and 72 h (47 and 81%, respectively) and increased in the middle-aged rats (193 and 389%, respectively). Water restriction did not change cardiovascular endothelial and neuronal NOS protein levels in any group.
Conclusion: NO pathways could contribute to the development of age-related cardiovascular adaptation to volume depletion induced by water restriction.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s00394-011-0183-6 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Water Spillover to Expedite Two-Electron Oxygen Reduction.
Adv Mater
January 2025
Key Laboratory for Soft Chemistry and Functional Materials (Ministry of Education), School of Chemistry and Chemical Engineering, School of Energy and Power Engineering, Nanjing University of Science and Technology, Nanjing, 210094, China.
Limited by the activity-selectivity trade-off relationship, the electrochemical activation of small molecules (like O, N and CO) rapidly diminishes Faradaic efficiencies with elevated current densities (particularly at ampere levels). Nevertheless, some catalysts can circumvent this restriction in a two-electron oxygen reduction reaction (2e ORR), a sustainable pathway for activating O to hydrogen peroxide (HO). Here we report 2e ORR expedited in a fluorine-bridged copper metal-organic framework catalyst, arising from the water spillover effect.
View Article and Find Full Text PDFLignocellulose biosorbents: Unlocking the potential for sustainable environmental cleanup.
Int J Biol Macromol
January 2025
Amity Institute of Pharmacy, Amity University Haryana, Amity Education Valley, Panchgaon, Manesar, Gurugram, Haryana 122413, India. Electronic address:
Climate change, the overconsumption of fossil fuels, and rapid population and economic growth have collectively driven a growing emphasis on environmental sustainability and the need for effective resource management. Chemicals or materials not currently regulated are known as contaminants of emergent concern (CECs). Nevertheless, wastewater is thought to be its main source, and worries about its probable presence in the environment are growing due to its potential damage to human and environmental health.
View Article and Find Full Text PDFModel-based scenario analysis to support the operation of solar photo-Fenton plants.
J Environ Manage
January 2025
Solar Energy Research Centre (CIESOL), Joint Centre University of Almería-CIEMAT, Ctra. de Sacramento s/n, Almería, 04120, Spain; Chemical Engineering Department, University of Almería, Carretera de Sacramento s/n, Almería, 04120, Spain.
Model-based tools applied to wastewater management have been identified as an emerging solution to address the associated challenges related to the optimization of the technologies, meeting more restricted water quality standards. Thus, for the first time, the demonstration of the solar photo-Fenton process for microcontaminant removal in the operating environment of a model-based tool is reported. This tool aids in determining the right cost-effective seasonal strategy for a 37-m demonstration-scale photoreactor operating in a rural wastewater treatment plant.
View Article and Find Full Text PDFMechanism of structural and functional changes of matcha bread dough during freezing storage.
Food Chem
December 2024
College of Food and Health, Zhejiang Agriculture and Forestry University, No. 666 Wusu Road, Linan District, 311300 Hangzhou, Zhejiang Province, China. Electronic address:
This study aimed to investigate the effects of freezing duration and matcha concentration on the rheological properties, moisture distribution, and multiscale structure of dough. The results indicated that both freezing and high concentrations of matcha (≥1 %) significantly reduced the stiffness of the dough matrix, restricted its ability to expand during fermentation, and disrupted the structure of gluten protein. Furthermore, freezing induced moisture redistribution within the dough.
View Article and Find Full Text PDFThe potential of urinary miR-200c-3p as a biomarker of fluorosis in rats.
Ecotoxicol Environ Saf
January 2025
Key Lab of Etiology and Epidemiology, Education Bureau of Heilongjiang Province & Ministry of Health (23618504), Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, Heilongjiang Province 150081, China. Electronic address:
Fluorine is a strong oxidizing element and excessive intake can have harmful effects, particularly on the body's calcified tissues. Recent studies have demonstrated a link between miRNA and fluorosis. This study aimed to evaluate the time-dose-effect relationship of miR-200c-3p in plasma, urine and cartilage of rats with drinking water fluorosis, and to explore its potential as a biomarker.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!