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Evaluation of the extracranial "multifocal arcuate sign," a novel MRI finding for the diagnosis of giant cell arteritis, on STIR and contrast-enhanced T1-weighted images.
BMC Med Imaging
June 2024
Department of Radiology, Division of Diagnostic Radiology, Yamagata University Faculty of Medicine, 2-2- 2 Iida-Nishi, Yamagata, 990-9585, Japan.
Background: While early diagnosis of giant cell arteritis (GCA) based on clinical criteria and contrast-enhanced MRI findings can lead to early treatment and prevention of blindness and cerebrovascular accidents, previously reported diagnostic methods which utilize contrast-enhanced whole head images are cumbersome. Diagnostic delay is common as patients may not be aware of initial symptoms and their significance. To improve current diagnostic capabilities, new MRI-based diagnostic criteria need to be established.
View Article and Find Full Text PDFAnalysis of prognostic factors and the role of epilepsy in neurosurgical patients with brain metastases.
Surg Neurol Int
March 2024
Department of Neurosurgery, Università Politecnica delle Marche, Ancona, Italy.
Background: Brain metastases (BMs) represent the most frequent brain tumors in adults. The identification of key prognostic factors is essential for choosing the therapeutic strategy tailored to each patient. Epilepsy can precede several months of other clinical presentations of BMs.
View Article and Find Full Text PDFCorrelation of Serum Endocan Level With Apoptosis Indicators and Severity of Atherosclerotic Lesions of Coronary Arteries in Patients With Coronary Heart Disease.
Kardiologiia
December 2023
Sevastopol State University; Sechenov Academic Research Institute of Physical Methods of Treatment, Medical Climatology, and Rehabilitation.
Aim To study the relationship of blood serum concentration of endocan with indexes of apoptosis and clinical and instrumental characteristics of patients with ischemic heart disease (IHD).Material and methods The study included 176 subjects (105 men and 71 women). 150 of them were diagnosed with IHD and 26 were healthy volunteers.
View Article and Find Full Text PDFSchwanoma of the cervical sympathetic chain: A case report.
Int J Surg Case Rep
September 2023
Department of Pathology, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Introduction And Importance: Any cranial, peripheral, or autonomic nerve in the body can give rise to a benign, slowly growing encapsulated nerve sheath tumor known as a schwannoma. The majority of parapharyngeal extracranial schwannomas, which typically have vagal origins, are located there. When they first appear, most swannomas are asymptomatic.
View Article and Find Full Text PDFGenomic analysis and clinical correlations of non-small cell lung cancer brain metastasis.
Nat Commun
August 2023
Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Up to 50% of patients with non-small cell lung cancer (NSCLC) develop brain metastasis (BM), yet the study of BM genomics has been limited by tissue access, incomplete clinical data, and a lack of comparison with paired extracranial specimens. Here we report a cohort of 233 patients with resected and sequenced (MSK-IMPACT) NSCLC BM and comprehensive clinical data. With matched samples (47 primary tumor, 42 extracranial metastatic), we show CDKN2A/B deletions and cell cycle pathway alterations to be enriched in the BM samples.
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