AI Article Synopsis
- The study examines the link between the Val158Met polymorphism of the COMT gene and aggression in patients with schizophrenia over a 6-year period.
- It involves a cohort of 141 patients, with 115 completing assessments, and 80 being genotyped and rated for aggression.
- Results indicate that patients with the Met/Met genotype exhibited higher levels of aggressive behavior than those with the Val/Val genotype, possibly due to less effective inactivation of norepinephrine.
Article Abstract
Although the etiology of aggression is multifactorial, many studies have associated the Val158Met polymorphism of the COMT with aggression in schizophrenia. This study tests the hypothesis that Met/Met patients display more episodes of aggression and violent behaviour than Val/Val patients in a 6 year follow-up cohort of subjects with schizophrenia in contact with the South-Verona Community-based Mental Health Service. Out of the 141 subjects with an ICD-10 SCAN-confirmed diagnosis of schizophrenia, 115 completed both baseline and follow-up assessments (81.6% of the baseline cohort). Of these, 80 subjects (70%) were genotyped and rated for aggression using the Overt Aggression Scale. Met/Met homozygous patients had higher aggressive behaviour compared to Val/Val homozygous subjects. Antipsychotic dosage, alcohol and drug abuse were taken into account as confounders. The Met/Met genotype of COMT may have an effect on aggressive behaviour in schizophrenia because norepinephrine is less effectively inactivated.
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| http://dx.doi.org/10.1016/j.neulet.2011.03.018 | DOI Listing |
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